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Effects of adjuvant chemotherapy on survival of patients with stage IB non-small cell lung cancer with visceral pleural invasion

  • Original Article – Cancer Research
  • Published:
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Abstract

Background

Adjuvant chemotherapy could improve the prognosis of stage II–III non-small cell lung cancer (NSCLC). However, its influences on stage IB were controversial. The purpose of this study was to investigate whether patients with stage IB NSCLC could benefit from adjuvant chemotherapy.

Methods

Stage IB NSCLC in 2010–2015 was selected from the surveillance, epidemiology, and end result database. Chi square test was used to compare the clinical characteristics of patients with different adjuvant chemotherapy status. Kaplan–Meier survival curves were plotted by the log-rank test. Cox proportional hazard regression was used to perform multivariate analysis on overall survival (OS), and the life table method was employed to calculate 1-, 3-, and 5-year survival rates.

Results

A total of 2915 patients were included in this study, and the number of patients with visceral pleural invasion (VPI) was 1096 (37.6%), of which 145 (13.2%) received adjuvant chemotherapy. There was no statistical difference in OS among the total population with or without chemotherapy (p = 0.295), nor in patients with VPI (p = 0.216). In patients with VPI, the 1-, 3-, 5-year survival curves of patients who are receiving adjuvant chemotherapy showed an upward trend compared with patients who did not. Additionally, female, high differentiated, adenocarcinoma, and tumor size ≤ 3 cm were also independent prognostic factors for improving the prognosis of patients with VPI.

Conclusion

In our study, stage IB NSCLC did not benefit from adjuvant chemotherapy, even in patients with VPI. However, the significance of adjuvant chemotherapy in patients with VPI is still worth further exploration.

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Funding

This work was supported by a Grant from the International Science and Technology Cooperation Project of the Changzhou Science and Technology Bureau (number CZ20140016).

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Author notes

  1. Jun Xie, Xian Zhang and Song Hu contributed equally to this work and are co-first authors.

Authors and Affiliations

  1. Department of Respiration, First People’s Hospital of Changzhou, Third Affiliated Hospital of Soochow University, Juqian Road No.185, Changzhou, China

    Jun Xie, Xian Zhang, Song Hu, Wan-Da Peng, Yan Li, Su-Juan Zhang & Chong Li

  2. Department of Tumor Biological Treatment, First People’s Hospital of Changzhou, Third Affiliated Hospital of Soochow University, Juqian Road No.185, Changzhou, China

    Bin Xu

  3. Department of Pathology, First People’s Hospital of Changzhou, Third Affiliated Hospital of Soochow University, Juqian Road No.185, Changzhou, China

    Qing Li

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  1. Jun Xie
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  2. Xian Zhang
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  3. Song Hu
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  5. Bin Xu
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  6. Yan Li
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Contributions

JX, XZ, SH, WDP, BX, YL, SJZ, QL, and CL developed the study. JX, XZ, and SH are contributors in writing the manuscript. WDP, BX, and YL analyzed the patient data. SJZ, QL, and CL completed the final review of the manuscript. All authors discussed the results and approved the final manuscript.

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Correspondence to Qing Li or Chong Li.

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Xie, J., Zhang, X., Hu, S. et al. Effects of adjuvant chemotherapy on survival of patients with stage IB non-small cell lung cancer with visceral pleural invasion. J Cancer Res Clin Oncol 146, 2231–2239 (2020). https://doi.org/10.1007/s00432-020-03276-w

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  • DOI: https://doi.org/10.1007/s00432-020-03276-w

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