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The survival impact of postoperative complications after curative resection in patients with esophageal squamous cell carcinoma: propensity score-matching analysis

Journal of Cancer Research and Clinical Oncology volume 146, pages 1351–1360 (2020)Cite this article

Abstract

Purpose

The relationship between postoperative complications and long-term survival after surgery for esophageal squamous cell carcinoma (ESCC) is controversial.

Method

A total of 210 patients with ESCC who underwent subtotal esophagectomy with a reconstructed gastric tube were investigated according to the development of postoperative complications. The associations of age, gender, T and N factors, and pStage with grade 0–2 complications (NSC) and grade 3 and higher complications (SC) were compared by propensity score-matching analysis. Fifty-one pairs of NSC and SC groups were selected for the final analysis. We divided 102 patients between the NSC and SC groups or between the no pulmonary complication (NPC) and the pulmonary complication (PC) groups. The overall survival (OS) and disease-free survival (DFS) were determined by the Kaplan–Meier method and were compared by log-rank tests. Possible predictors of OS and DFS were subjected to univariate analysis and multivariate Cox proportional hazard regression analysis.

Results

The propensity score matching revealed that the 5-year OS and DFS of the NSC group were not different from those of the SC group. However, the 5-year OS of the PC group was significantly worse than that of the NPC group, while no significant differences were observed in the DFS between the PC and NPC groups. In the multivariate analysis, UICC pStage, pulmonary complication, and American Heart Association (AHA) classification for OS and UICC pStage for DFS were significant prognostic factors.

Conclusion

The OS and DFS did not differ in patients with or without severe postoperative complications. However, postoperative pulmonary complications were independent predictors of poorer OS, but not DFS, in patients who underwent R0 resection for ESCC.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Affiliations

  1. Department of Surgery, Fukuoka Sanno Hospital, 3-6-45 Momochi-hama, Sawara-ku, Fukuoka, 814-0001, Japan

    Manabu Yamamoto

  2. Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1395, Japan

    Manabu Yamamoto, Daisuke Yoshida, Shohei Yamaguchi, Mitsuhiko Ohta, Akinori Egashira, Masahiko Ikebe, Masaru Morita & Yasushi Toh

  3. Department of Biostatistics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, Yamaguchi, 755-8505, Japan

    Mototsugu Shimokawa

Authors
  1. Manabu Yamamoto
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  2. Mototsugu Shimokawa
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  3. Daisuke Yoshida
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  4. Shohei Yamaguchi
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  5. Mitsuhiko Ohta
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  7. Masahiko Ikebe
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  8. Masaru Morita
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  9. Yasushi Toh
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Corresponding author

Correspondence to Manabu Yamamoto.

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Ethical approval

The study design was approved by the ethics committees of National Kyushu Cancer Center, Fukuoka, Japan, and Fukuoka Sanno Hospital, Fukuoka, Japan.

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Informed consent was obtained from all patients.

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Yamamoto, M., Shimokawa, M., Yoshida, D. et al. The survival impact of postoperative complications after curative resection in patients with esophageal squamous cell carcinoma: propensity score-matching analysis. J Cancer Res Clin Oncol 146, 1351–1360 (2020). https://doi.org/10.1007/s00432-020-03173-2

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  • DOI: https://doi.org/10.1007/s00432-020-03173-2

Keywords

  • Esophageal cancer
  • Postoperative complications
  • Survival
  • Propensity matching