MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review

Liu, Jianrong; Ke, Fei; Chen, Tingting; Zhou, Qing; Weng, Lingling; Tan, Jiani; Shen, Weixing; Li, Liu; Zhou, Jinyong; Xu, Changliang; Cheng, Haibo; Zhou, Jinrong

doi:10.1007/s00432-020-03172-3

Review – Cancer Research
Published: 07 March 2020

MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review

Jianrong Liu¹,
Fei Ke²,
Tingting Chen³,
Qing Zhou³,
Lingling Weng⁴,
Jiani Tan³,
Weixing Shen³,
Liu Li³,
Jinyong Zhou⁵,
Changliang Xu³,
Haibo Cheng³ &
Jinrong Zhou¹

Journal of Cancer Research and Clinical Oncology volume 146, pages 809–820 (2020)Cite this article

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Abstract

Purpose

MicroRNAs (miRNAs) participate in a variety of biological processes, including tumorigenesis, progression, invasion, and drug resistance to multiple cancers. Phosphatase and tensin homolog (PTEN) is a cancer suppressor gene that has been certified to be regulated by miRNAs in various tumors, including colorectal cancer (CRC). In this review, we screened articles focusing on low PTEN expression in CRC, observed the expression of related miRNAs, analyzed their correlation and relationship with clinicopathological features, and discussed the possibility of these miRNAs as prognostic molecules.

Methods

We conducted a systematic search for articles published in the Web of Science, PubMed and EBSCO databases between January 1, 2002, and July 18, 2019. We identified these studies by using combinations of the following index entries and key words: ‘colorectal tumor OR colorectal neoplasm OR colorectal carcinoma OR colorectal cancer OR CRC’, ‘protein tyrosine phosphatase OR PTEN’, and ‘microRNA OR MiRNA OR miRNA OR MicroRNA’. Moreover, we evaluated the underlying association between alterations in PTEN and CRC prognosis.

Results

PTEN expression was obviously lower in CRC tissues than in normal mucosa. However, PTEN expression did not differ significantly between adenoma and normal tissues. PTEN tends to be negatively associated with tumor size and metastasis. MiR-21, miR-200a, miR-543, miR-32, miR-92a, miR-26a, miR-106a and miR-181a were correlated with the downregulation of PTEN. MiR-26a, miR-106a and miR-181a were obviously higher in CRC tissues than in normal tissues, while PTEN was downregulated in CRC tissues. Additionally, miRNAs were mainly positively correlated with distant metastasis, followed by TNM stage. The relationship between miRNAs and tumor differentiation is controversial. However, there were no significant differences between miRNAs and either sex or age.

Conclusions

The loss of PTEN may be a diagnostic factor for CRC patients. The above-mentioned miRNAs may function as oncogenes in CRC and represent potential targets for CRC therapy. However, further prospective clinical studies are necessary.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (81804073, 81930117, and 81973523), the Natural Science Foundation of Colleges and Universities in Jiangsu Province (17KJA360002 and 19KJB360011), and a subproject of the National Key Research and Development Plan of the Ministry of Science and Technology (2017YFC1700602).

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Affiliations

School of Medicine and Life Sciences, Nanjing University of Chinese Medicine, Nanjing, 210046, Jiangsu, People’s Republic of China
Jianrong Liu & Jinrong Zhou
Pathology Department, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China
Fei Ke
Jiangsu Collaborative Innovation Center of TCM Prevention and Treatment of Tumor, The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, 210046, Jiangsu, People’s Republic of China
Tingting Chen, Qing Zhou, Jiani Tan, Weixing Shen, Liu Li, Changliang Xu & Haibo Cheng
Imaging Department, Nanjing Hospital of Chinese Medicine, Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China
Lingling Weng
Central Laboratory, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, People’s Republic of China
Jinyong Zhou

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Jianrong Liu
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Fei Ke
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Tingting Chen
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Qing Zhou
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Lingling Weng
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Jiani Tan
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Weixing Shen
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Liu Li
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Jinyong Zhou
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Changliang Xu
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Haibo Cheng
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Jinrong Zhou
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Correspondence to Haibo Cheng or Jinrong Zhou.

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Liu, J., Ke, F., Chen, T. et al. MicroRNAs that regulate PTEN as potential biomarkers in colorectal cancer: a systematic review. J Cancer Res Clin Oncol 146, 809–820 (2020). https://doi.org/10.1007/s00432-020-03172-3

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Received: 30 December 2019
Accepted: 27 February 2020
Published: 07 March 2020
Issue Date: April 2020
DOI: https://doi.org/10.1007/s00432-020-03172-3

Keywords

Phosphatase and tensin homolog (PTEN)
MicroRNAs (miRNAs)
Diagnosis
Biomarker
Prognosis
Colorectal cancer (CRC)