Abstract
Purpose
Age and obesity are well-known risk factors for various cancers, but the potential roles of age and obesity in lung cancer, especially in those with activating EGFR mutations, have not been thoroughly evaluated. The aim of this retrospective study is to evaluate the associations between the sex-specific incidence of EGFR mutations and age and obesity.
Methods
We conducted a retrospective study based on the data from 1378 lung adenocarcinoma cases. The degree of obesity was categorized by body mass index (BMI). The associations between EGFR mutational status and clinical factors, including stage, smoking history, age group (≤45 years, 46–55, 56–65 and >65), and BMI group (<18.5 kg/m2, 18.5–22.9, 23.0–24.9 and ≥25.0) were analyzed using logistic regression models for each sex.
Results
In men, the incidence of EGFR mutation was inversely associated with age (adjusted odds ratio [OR] for age group = 0.76, p-trend = 0.003) and positively associated with obesity (adjusted OR for BMI group = 1.23, p-trend = 0.04). In contrast, in women, the incidence of EGFR mutation was positively associated with age (adjusted OR for age group = 1.19, p-trend = 0.02). However, the incidence of EGFR mutation was not statistically associated with obesity (adjusted OR for BMI group = 1.03, p-trend = 0.76).
Conclusions
Our data suggests that age and obesity may contribute to the sex-specific incidence of EGFR mutation in lung adenocarcinoma in different manners.
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The authors declare that they have no conflict of interest.
Funding
This study was partly supported by a Grant of the Korea Institute of Radiological and Medical Sciences (KIRAMS), funded by Ministry of Science, ICT and Future Planning, Republic of Korea (50460-2016/50475-2017).
Ethical approval
This study was approved by the Institutional Review Board of Korea Cancer Center Hospital (K-1502-002-034) and Asan Medical Center (2015-0785) on March 2015. All procedures performed in study involving human participants were in accordance with the ethical standards of the institutional research committee and with the Declaration of Helsinki revised at the 64th WMA General Assembly in 2013 or comparable ethical standards.
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EGFR mutational testing was performed after obtaining informed consent.
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Kim, HR., Kim, S.Y., Kim, C.H. et al. Sex-specific incidence of EGFR mutation and its association with age and obesity in lung adenocarcinomas: a retrospective analysis. J Cancer Res Clin Oncol 143, 2283–2290 (2017). https://doi.org/10.1007/s00432-017-2473-8
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DOI: https://doi.org/10.1007/s00432-017-2473-8