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The combination of preoperative PET/CT and sentinel lymph node biopsy in the surgical management of early-stage cervical cancer

  • Original Article – Clinical Oncology
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Introduction

The aim of the study was to evaluate the use of PET/CT and/or SLN mapping alone or in combination in cervical cancer patients.

Materials and methods

Data on stage IA1-IIA cervical cancer patients undergoing PET/CT and SLN mapping were retrospectively collected. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of PET/CT and SLN mapping, alone or in combination, in identifying cervical cancer patients with lymph node metastases were calculated.

Results

Sixty patients met the inclusion criteria. PET/CT showed a sensitivity of 68%, a specificity of 84%, a PPV of 61% and a NPV of 88% in detecting lymph nodal metastases. SLN mapping showed a sensitivity of 93%, a specificity of 100%, a PPV of 100% and a NPV of 97%. The combination of PET/CT and SLN mapping showed a sensitivity of 100%, a specificity of 86%, a PPV of 72% and a NPV of 100%. For patients with tumors of >2 cm in diameter, the PET/CT showed a sensitivity of 68%, a specificity of 72%, a PPV of 61% and a NPV of 86%. SLN mapping showed a sensitivity of 93%, a specificity of 100%, a PPV of 100% and a NPV of 95%. The combination of PET/CT and SLN mapping showed a sensitivity of 100%, a specificity of 76%, a PPV of 72% and a NPV of 100%.

Conclusion

PET/CT represents a “safety net” that helps the surgeon in identifying metastatic lymph nodes, especially in patients with larger tumors.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, University Hospital of Bern and University of Bern, Effingerstrasse 102, 3010, Bern, Switzerland

    Andrea Papadia, Maria Luisa Gasparri, Sophie Genoud & Michael D. Mueller

  2. Department of Nuclear Medicine, Bern University Hospital and University of Bern, Bern, Switzerland

    Klaeser Bernd

Authors
  1. Andrea Papadia
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  2. Maria Luisa Gasparri
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  3. Sophie Genoud
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  4. Klaeser Bernd
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  5. Michael D. Mueller
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Corresponding author

Correspondence to Andrea Papadia.

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Conflict of interest

All of the authors declare no conflict of interest.

Funding

This study was not supported by any funding.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. IRB approval was obtained.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Papadia, A., Gasparri, M.L., Genoud, S. et al. The combination of preoperative PET/CT and sentinel lymph node biopsy in the surgical management of early-stage cervical cancer. J Cancer Res Clin Oncol 143, 2275–2281 (2017). https://doi.org/10.1007/s00432-017-2467-6

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  • DOI: https://doi.org/10.1007/s00432-017-2467-6

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