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Impact of metastasectomy on prognosis in patients treated with targeted therapy for metastatic renal cell carcinoma

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

We evaluated the value of metastasectomy in patients treated with targeted therapy for metastatic renal cell carcinoma (mRCC).

Methods

The medical records of 325 patients who presented with mRCC were reviewed; among these patients, 33 underwent complete metastasectomy followed by targeted therapy (complete metastasectomy group), 29 underwent incomplete metastasectomy followed by targeted therapy (incomplete metastasectomy group), and 263 treated with targeted therapy alone (non-metastasectomy group). We estimated progression-free and overall survivals using Kaplan–Meier curves. A Cox proportional hazards regression model was used to estimate the prognostic significance of metastasectomy.

Results

Clinicopathological variables did not differ among the three groups except for age, history of nephrectomy, type of metastasis, the International Metastatic Renal Cell Carcinoma Database Consortium risk groups, histology, and bone metastasis. The median progression-free survivals were 29.5, 18.8, and 14.8 months in the complete, incomplete, and non-metastasectomy groups (p < 0.001). Complete metastasectomy (hazard ratio 0.431, p = 0.001) was an independent predictor of disease progression, along with targeted agents, risk groups, sarcomatoid feature, and number of metastatic sites. The median overall survivals were 92.5, 29.6, and 23.5 months in the complete, incomplete, and non-metastasectomy groups (p < 0.001). Complete metastasectomy (hazard ratio 0.378, p = 0.001) was an independent predictor of overall survival, along with targeted agents, type of metastasis, risk groups, sarcomatoid feature, and number of metastatic sites.

Conclusions

Complete metastasectomy performed before targeted therapy might improve progression-free and overall survivals in patients with mRCC.

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Authors and Affiliations

  1. Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-Ro 43-Gil, Songpa-Gu, Seoul, 05505, Korea

    Dalsan You, In Gab Jeong, Cheryn Song, Bumsik Hong, Jun Hyuk Hong, Hanjong Ahn & Choung-Soo Kim

  2. Department of Urology, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Changwon, Gyeongsangnam, Korea

    Chunwoo Lee

  3. Department of Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Jae-Lyun Lee

Authors
  1. Dalsan You
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  2. Chunwoo Lee
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  3. In Gab Jeong
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  4. Cheryn Song
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  5. Jae-Lyun Lee
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  6. Bumsik Hong
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  7. Jun Hyuk Hong
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  8. Hanjong Ahn
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  9. Choung-Soo Kim
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Corresponding author

Correspondence to Choung-Soo Kim.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Institutional Review Board of the Asan Medical Center (2015–0808). All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of the Asan Medical Center and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

The Institutional Review Board of the Asan Medical Center waived the requirement for informed consent because of the retrospective design of this study.

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You, D., Lee, C., Jeong, I.G. et al. Impact of metastasectomy on prognosis in patients treated with targeted therapy for metastatic renal cell carcinoma. J Cancer Res Clin Oncol 142, 2331–2338 (2016). https://doi.org/10.1007/s00432-016-2217-1

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  • DOI: https://doi.org/10.1007/s00432-016-2217-1

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