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Interstitial growth as an aggressive growth pattern in primary lung cancer

  • Original Article – Clinical Oncology
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Abstract

Purpose

Interstitial growth (IG), which is defined as tumor cells continuously growing into the alveolar septa at the tumor periphery, was originally reported as a growth pattern of metastatic sarcoma of the lung. On the other hand, IG in the primary lung cancers has not been well described. This study aimed to examine clinicopathological features of primary lung cancer that harbors IG.

Methods

A total of 2558 primary lung cancers which were resected from 2003 to 2012 in our hospital were examined for IG. We compared clinicopathological data and prognoses between patients with IG+ and IG− specimens.

Results

Thirty-three cases out of 2558 (1.3 %) had IG components. IG was significantly more associated with positive smoking history, advanced pathological stage, presence of vascular invasion and pleural invasion. Thirty-three IG+ cases include nine pleomorphic carcinoma, nine squamous cell carcinoma and eight adenocarcinoma. Interestingly, nine (24 %) out of 38 pleomorphic carcinoma specimens had IG components, which was a higher rate than any other histological subtypes. The IG+ cancers had significantly shorter overall and recurrence-free survival than did the IG− cancers.

Conclusions

We firstly reported on IG in various types of primary lung cancer. IG appears to be a sign of an aggressive lung cancer phenotype, mainly found in pleomorphic carcinoma.

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Authors and Affiliations

  1. Division of Pathology, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan

    Shigeki Suzuki, Takeshi Kuwata, Chisako Yamauchi & Genichiro Ishii

  2. Division of Thoracic Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan

    Shigeki Suzuki, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida & Masahiro Tsuboi

Authors
  1. Shigeki Suzuki
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  2. Keiju Aokage
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  3. Tomoyuki Hishida
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  4. Junji Yoshida
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  5. Takeshi Kuwata
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  6. Chisako Yamauchi
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  7. Masahiro Tsuboi
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  8. Genichiro Ishii
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Corresponding author

Correspondence to Genichiro Ishii.

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Conflict of interest

Shigeki S declares that he has no conflict of interest. Keiju A declares that he has no conflict of interest. Tomoyuki H declares that he has no conflict of interest. Junji Y declares that he has no conflict of interest. Takeshi K declares that he has no conflict of interest. Chisako Y declares that she has no conflict of interest. Masahiro T declares that he has no conflict of interest. Genichiro I declares that he has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Suzuki, S., Aokage, K., Hishida, T. et al. Interstitial growth as an aggressive growth pattern in primary lung cancer. J Cancer Res Clin Oncol 142, 1591–1598 (2016). https://doi.org/10.1007/s00432-016-2168-6

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  • DOI: https://doi.org/10.1007/s00432-016-2168-6

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