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Bone morphogenetic protein signaling in musculoskeletal cancer

  • Review – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) superfamily of proteins; they were initially named after their ability to induce ectopic bone formation. Published studies have proved BMPs’ role in a variety of biological processes such as embryogenesis and patterning of body axes, and maintaining adult tissue homeostasis. Other studies have focused on BMPs properties, functions and possible involvement in skeletal diseases, including cancer.

Methods

A literature search mainly paying attention to the role of BMPs in musculoskeletal tumors was performed in electronic databases.

Results

This article discusses BMPs synthesis and signaling, and summarizes their prominent roles in the skeletal system for the differentiation of osteoblasts, osteocytes and chondrocytes.

Conclusions

The review emphasizes on the role of BMP signaling in the initiation and progression of musculoskeletal cancer.

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Authors and Affiliations

  1. First Department of Orthopaedics, Athens University Medical School, Attikon University Hospital, Athens, Greece

    Andreas F. Mavrogenis & Panayotis N. Soucacos

  2. Department of Orthopaedics, Istituto Ortopedico Rizzoli, University of Bologna, Via Pupilli, 1, 40136, Bologna, Italy

    Andrea Angelini

  3. Orthopaedic Research and Education Center, “Panayotis N. Soucacos”, Athens University Medical School, Attikon University Hospital, Athens, Greece

    Myrto Bami, Mandy Milonaki, Evanthia Mitsiokapa & Dimitrios Stamoulis

Authors
  1. Myrto Bami
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  2. Andreas F. Mavrogenis
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  3. Andrea Angelini
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  4. Mandy Milonaki
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  5. Evanthia Mitsiokapa
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  6. Dimitrios Stamoulis
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  7. Panayotis N. Soucacos
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Corresponding author

Correspondence to Andreas F. Mavrogenis.

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Conflict of interest

None of the authors had any financial or personal relationships with other people or organizations that could inappropriately influence (bias) their work. Myrto Bami, Andrea Angelini, Mandy Milonaki, Evanthia Mitsiokapa, Dimitrios Stamoulis, Andreas F. Mavrogenis, Panayotis N. Soucacos declares that they have no conflict of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Bami, M., Mavrogenis, A.F., Angelini, A. et al. Bone morphogenetic protein signaling in musculoskeletal cancer. J Cancer Res Clin Oncol 142, 2061–2072 (2016). https://doi.org/10.1007/s00432-016-2149-9

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  • DOI: https://doi.org/10.1007/s00432-016-2149-9

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