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TRPM8: a potential target for cancer treatment

Abstract

Transient receptor potential (TRP) cation channel superfamily plays critical roles in variety of processes, including temperature perception, pain transduction, vasorelaxation, male fertility, and tumorigenesis. One of seven families within the TRP superfamily of ion channels, the melastatin, or TRPM family comprises a group of eight structurally and functionally diverse channels. Of all the members of TRPM subfamily, TRPM8 is the most notable one. A lot of literatures have demonstrated that transient receptor potential melastatin 8 (TRPM8) could perform a myriad of functions in vertebrates and invertebrates alike. In addition to its well-known function in cold sensation, TRPM8 has an emerging role in a variety of biological systems, including thermoregulation, cancer, bladder function, and asthma. Recent studies have shown that TRPM8 is necessary to the initiation and progression of tumors, and the aberrant expression of TRPM8 was found in varieties of tumors, such as prostate tumor, melanoma, breast adenocarcinoma, bladder cancer, and colorectal cancer, making it a novel molecular target potentially useful in the diagnosis and treatment of cancer. This review outlines our current understanding on the role of TRPM8 in occurrence and development of different kinds of tumor and also includes discussion about the regulation of TRPM8 during carcinogenesis as well as therapeutic potential of targeting TRPM8 in tumor, which may be utilized for a potential pharmacological use as a target for anti-cancer therapy.

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Acknowledgments

The authors thank the financial support from the National Natural Science Foundation of China (Nos. 81173174, 81202655, and 81403260); 2013 Program for Excellent Scientific and Technological Innovation Team of Jiangsu Higher Education; A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); Jiangsu College graduate research and innovation projects (Nos. CXLX12_0587 and KYZZ_0270).

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Correspondence to Yin Lu.

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The authors declare that there is no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Zhaoguo Liu and Hongyan Wu have contributed equally to this work.

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Liu, Z., Wu, H., Wei, Z. et al. TRPM8: a potential target for cancer treatment. J Cancer Res Clin Oncol 142, 1871–1881 (2016). https://doi.org/10.1007/s00432-015-2112-1

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  • DOI: https://doi.org/10.1007/s00432-015-2112-1

Keywords

  • TRPM8
  • Thermoregulation
  • Pain transduction
  • Tumor
  • Anti-cancer therapy