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Estrogen receptor alpha polymorphisms and the risk of prostate cancer development

  • Original Article – Cancer Research
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

The main purpose of the study was to evaluate the effect of two polymorphisms in the estrogen receptor alpha, rs2077647 and rs3798577, on the development of prostate cancer, their correlation with selected clinical characteristics, as well as consideration of potential interactions between four estrogen receptor alpha polymorphisms (rs2077647, rs3798577, PvuII, XbaI).

Methods

The study was performed using 395 patients with histologically verified prostate cancer and 253 healthy male controls.

Results

The CC genotype of rs2077647 was significantly associated with prostate cancer (OR = 1.61). No association was found between rs3798577 polymorphism and prostate cancer. After stratification of patients according to the age at diagnosis and Gleason score, we observed significant correlation between rs2077647 polymorphism and prostate cancer risk in patients diagnosed before the age of 60 as well as patients with Gleason score <7, while rs3798577 was significantly associated with prostate cancer risk development in patients older than 60 and with Gleason score ≥7. Double analysis of each combination of four studied polymorphisms showed that presence of at least three variant alleles was associated with prostate cancer risk in all combinations, while each containing rs3798577 was significantly associated with development of high-grade carcinomas.

Conclusions

The present study suggests that rs2077647 polymorphism may be a risk factor for prostate cancer especially in patients diagnosed before the age of 60, while rs3798577 polymorphism could probably serve rather as promoting factor in combination with other polymorphisms in estrogen receptor alpha contributing preferably to development of high-grade carcinomas.

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Acknowledgments

This work was supported by project “Competence Center for research and development in the field of diagnostics and therapy of oncological diseases”, ITMS: 26220220153, co-funded from EU sources and European Regional Development Fund and by projects supported by Ministry of Health of the Slovak Republic 2012/27-UKMA-4.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovak Republic

    Jana Jurečeková, Eva Babušíková, Monika Kmeťová & Dušan Dobrota

  2. Department of Urology, Jessenius Faculty of Medicine and University Hospital Martin, Comenius University in Bratislava, Martin, Slovak Republic

    Ján Kliment

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  1. Jana Jurečeková
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  2. Eva Babušíková
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  3. Monika Kmeťová
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  4. Ján Kliment
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  5. Dušan Dobrota
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Correspondence to Jana Jurečeková.

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Jurečeková, J., Babušíková, E., Kmeťová, M. et al. Estrogen receptor alpha polymorphisms and the risk of prostate cancer development. J Cancer Res Clin Oncol 141, 1963–1971 (2015). https://doi.org/10.1007/s00432-015-1966-6

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  • DOI: https://doi.org/10.1007/s00432-015-1966-6

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