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Meningiomas after cranial radiotherapy for childhood cancer: a single institution experience

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Purpose

Childhood cancer survivors (CCS) treated with cranial radiation therapy (CRT) are at risk of developing meningiomas. The aim of this study was to evaluate the cumulative incidence of meningiomas in a cohort of CCS who previously underwent CRT.

Methods

We considered all CCS who received CRT and were followed up at the “Transition Unit for Childhood Cancer Survivors” in Turin. Even though asymptomatic, they had at least one brain computed tomography or magnetic resonance imaging performed at a minimum interval of 10 years after treatment for pediatric cancer.

Results

We identified 90 patients (median follow-up 24.6 years). Fifteen patients developed meningioma (median time from pediatric cancer, 22.5 years). In four patients, it was suspected on the basis of neurological symptoms (i.e., headache or seizures), whereas all other cases, including five giant meningiomas, were discovered in otherwise asymptomatic patients. Multiple meningiomas were discovered in four CCS. Ten patients underwent surgical resection. An atypical meningioma (grade II WHO) was reported in four patients. One patient with multiple meningiomas died for a rapid growth of the intracranial lesions. A second neoplasm (SN) other than meningioma was diagnosed in five out of the 15 patients with meningioma and in ten out of the 75 CCS without meningioma. Cox multivariate analysis showed that the occurrence of meningioma was associated with the development of other SNs, whereas age, sex, or CRT dose had no influence.

Conclusions

CCS at risk of the development of meningioma deserve close clinical follow-up, especially those affected by other SNs.

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Acknowledgments

The authors would like to acknowledge U.G.I. (Unione Genitori Italiani contro il tumore dei bambini), for the ongoing support to clinical and research activities at the Transition Unit for Childhood Cancer Survivors.

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Transition Unit for Childhood Cancer Survivors, Department of Oncology, AOU Città della Salute e della Scienza di Torino, Via Cherasco 15, 10126, Turin, Italy

    Francesco Felicetti, Nicoletta Fortunati & Enrico Brignardello

  2. Oncological Endocrinology Unit, Department of Oncology, AOU Città della Salute e della Scienza di Torino, Turin, Italy

    Francesco Felicetti, Nicoletta Fortunati & Emanuela Arvat

  3. Neurosurgery Unit, Department of Neurosciences, AOU Città della Salute e della Scienza di Torino, Turin, Italy

    Diego Garbossa

  4. Pediatric Hematology-Oncology Unit, Department of Pediatric Sciences, AOU Città della Salute e della Scienza di Torino, Turin, Italy

    Eleonora Biasin & Franca Fagioli

  5. Neuro-Oncology Unit, Department of Neurosciences, AOU Città della Salute e della Scienza di Torino, Turin, Italy

    Roberta Rudà

  6. Neuroradiology Unit, Department of Neurosciences, AOU Città della Salute e della Scienza di Torino, Turin, Italy

    Dino Daniele

  7. Pediatric Endocrinology Unit, Department of Pediatric Sciences, AOU Città della Salute e della Scienza di Torino, Turin, Italy

    Andrea Corrias

Authors
  1. Francesco Felicetti
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  2. Nicoletta Fortunati
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  3. Diego Garbossa
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  4. Eleonora Biasin
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  5. Roberta Rudà
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  6. Dino Daniele
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  7. Emanuela Arvat
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  8. Andrea Corrias
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  9. Franca Fagioli
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  10. Enrico Brignardello
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Corresponding author

Correspondence to Enrico Brignardello.

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Felicetti, F., Fortunati, N., Garbossa, D. et al. Meningiomas after cranial radiotherapy for childhood cancer: a single institution experience. J Cancer Res Clin Oncol 141, 1277–1282 (2015). https://doi.org/10.1007/s00432-015-1920-7

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  • DOI: https://doi.org/10.1007/s00432-015-1920-7

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