Abstract
Purpose
Most patients with low-grade gliomas (LGGs) experience epileptic seizures as an initial symptom. However, the mechanism of LGG-related epilepsy is poorly understood. Genetic changes in brain tumors influence epileptic seizures, but few biomarkers have been associated with LGG-related seizures. We investigated the association between LGG-related epilepsy and tumor-specific molecular changes.
Methods
Clinical characteristics, RNA sequence data, and case follow-up data were reviewed for 76 patients with histologically confirmed LGG. Gene expression (n = 21,469) was compared between patients with preoperative epileptic seizures and those without preoperative epileptic seizures. The Engel classification was used at 6 months after surgery to evaluate the prognostic role of genes that passed the screen.
Results
Expression of RAD50 interactor 1 (RINT1) significantly differed between LGG patients with and without preoperative epileptic seizures (p = 0.003). This result was validated by applying the same analysis to RNA sequence data from The Cancer Genome Atlas (p = 0.048). Patients with high RINT1 expression were at increased risk of LGG-related seizures compared to those with low expression (p = 0.044). RINT1 was also identified as a predictor of seizure outcomes in patients with LGG at 6 months after tumor resection (p = 0.022).
Conclusions
Our results suggest that high RINT1 expression may represent a risk factor for LGG-related seizures and may be associated with seizure outcomes.
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Acknowledgments
This work was supported by funding from the National High Technology Research and Development Program (No. 2012AA02A508), the National Basic Research Program of China (No. 2015CB755500), the National Natural Science Foundation of China (No. 81301112), and the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (No. 2013BAI09B03).
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The authors declare no conflict of interest.
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Xing Fan and Yinyan Wang have contributed equally to this study.
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Fan, X., Wang, Yy., Zhang, Cb. et al. Expression of RINT1 predicts seizure occurrence and outcomes in patients with low-grade gliomas. J Cancer Res Clin Oncol 141, 729–734 (2015). https://doi.org/10.1007/s00432-014-1827-8
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DOI: https://doi.org/10.1007/s00432-014-1827-8