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Neoadjuvant therapy combined with a BMP regimen for treating penile cancer patients with lymph node metastasis: a retrospective study in China

  • Review – Clinical Oncology
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Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Background and aim

Combination chemotherapy is emerging in the management of advanced penile cancer. However, evidence-based chemotherapeutic regimens in the current guidelines are lacking. The aim of this study was to evaluate the efficacy of preoperative neoadjuvant chemotherapy combined with a BMP regimen including bleomycin (BLM), methopterin (MTX) and cisplatin (DDP) for treating advanced penile cancer patients.

Methods

We retrospectively audited the clinical and follow-up data of 24 penile cancer patients with fixed inguinal lymph node metastasis that were admitted in our hospital from 2001 to 2010 and received preoperative neoadjuvant chemotherapy.

Results

A total of 24 patients with advanced penile cancer (pN3) were recruited in this study. All patients received preoperative neoadjuvant chemotherapy combined with a BMP regimen. The average cycle of chemotherapy was two cycles (range 1–4 cycles). Among 24 adjuvant cases, 15 patients that responded to neoadjuvant chemotherapy underwent penectomy and inguinal lymphadenectomy. In contrast, nine cases did not respond to chemotherapy and received palliative local radiotherapy. Overall, the 1-, 2- and 5-year survival rates were 70.8, 50.0 and 45.8 %, respectively. The 5-year survival rate between the responder and non-responder groups was statistically significant (73.3 vs. 0 %, P < 0.001).

Conclusion

Neoadjuvant chemotherapy combined with a BMP regimen followed by surgery is beneficial to patients with advanced penile cancer.

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References

  • Ahmed T, Sklaroff R, Yagoda A (1984) Sequential trials of methotrexate, cisplatin and bleomycin for penile cancer. J Urol 132(3):465–468

    PubMed  CAS  Google Scholar 

  • Azrif M et al (2006) External-beam radiotherapy in T1-2 N0 penile carcinoma. Clin Oncol 18(4):320–325

    Article  CAS  Google Scholar 

  • Bermejo C et al (2007) Neoadjuvant chemotherapy followed by aggressive surgical consolidation for metastatic penile squamous cell carcinoma. J Urol 177(4):1335–1338

    Article  PubMed  Google Scholar 

  • Bevan-Thomas R, Slaton JW, Pettaway CA (2002) Contemporary morbidity from lymphadenectomy for penile squamous cell carcinoma: the M.D. Anderson cancer center experience. J Urol 167(4):1638–1642

    Article  PubMed  Google Scholar 

  • Bissada NK et al (2003) Multi-institutional long-term experience with conservative surgery for invasive penile carcinoma. J Urol 169(2):500–502

    Article  PubMed  Google Scholar 

  • Broders AC (1921) Squamous-cell epithelioma of the skin: a study of 256 cases. Ann Surg 73(2):141–160

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Crawshaw JW et al (2009) Sentinel lymph node biopsy using dynamic lymphoscintigraphy combined with ultrasound-guided fine needle aspiration in penile carcinoma. Br J Radiol 82(973):41–48

    Article  PubMed  CAS  Google Scholar 

  • Crook J, Ma C, Grimard L (2009) Radiation therapy in the management of the primary penile tumor: an update. World J Urol 27(2):189–196

    Article  PubMed  Google Scholar 

  • Culkin DJ, Beer TM (2003) Advanced penile carcinoma. J Urol 170:359–365

    Article  PubMed  Google Scholar 

  • Delaunay B et al (2013) Brachytherapy for penile cancer: efficacy and impact on sexual function. Brachytherapy pii:S1538–4721(13)00283–3. doi:10.1016/j.brachy.2013.06.001

  • Dexeus FH et al (1991) Combination chemotherapy with methotrexate, bleomycin and cisplatin for advanced squamous cell carcinoma of the male genital tract. J Urol 146(5):1284–1287

    PubMed  CAS  Google Scholar 

  • Di Lorenzo G et al (2012) Cisplatin and 5-fluorouracil in inoperable, stage IV squamous cell carcinoma of the penis. BJU Int 110(11 Pt B):E661–E666

    Article  PubMed  CAS  Google Scholar 

  • Edge SB, Compton CC (2010) The American joint committee on cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6):1471–1474

    Article  PubMed  Google Scholar 

  • Gagliano RG et al (1989) Cis-diamminedichloroplatinum in the treatment of advanced epidermoid carcinoma of the penis: a Southwest Oncology Group Study. J Urol 141(1):66–67

    PubMed  CAS  Google Scholar 

  • Greene FL (2002) The American joint committee on cancer: updating the strategies in cancer staging. Bull Am Coll Surg 87(7):13–15

    PubMed  Google Scholar 

  • Haas GP et al (1999) Cisplatin, methotrexate and bleomycin for the treatment of carcinoma of the penis: a Southwest Oncology Group study. J Urol 161(6):1823–1825

    Article  PubMed  CAS  Google Scholar 

  • Hegarty PK et al (2006) A prospective study of 100 cases of penile cancer managed according to European Association of Urology guidelines. BJU Int 98(3):526–531

    Article  PubMed  Google Scholar 

  • Horenblas S et al (2000) Detection of occult metastasis in squamous cell carcinoma of the penis using a dynamic sentinel node procedure. J Urol 163(1):100–104

    Article  PubMed  CAS  Google Scholar 

  • Hrab M et al (2012) Penile cancer: case report and literature review. Ginekol Pol 83(1):67–70

    PubMed  Google Scholar 

  • Joerger M et al (2004) Major tumor regression after paclitaxel and carboplatin polychemotherapy in a patient with advanced penile cancer. Urology 63(4):778–780

    Article  PubMed  CAS  Google Scholar 

  • Kroon BK et al (2005) Patients with penile carcinoma benefit from immediate resection of clinically occult lymph node metastases. J Urol 173(3):816–819

    Article  PubMed  CAS  Google Scholar 

  • Larke NL et al (2011) Male circumcision and penile cancer: a systematic review and meta-analysis. Cancer Causes Control 22(8):1097–1110

    Article  PubMed  PubMed Central  Google Scholar 

  • Leijte JA et al (2007) Neoadjuvant chemotherapy in advanced penile carcinoma. Eur Urol 52(2):488–494

    Article  PubMed  CAS  Google Scholar 

  • McDougal WS et al (1986) Treatment of carcinoma of the penis: the case for primary lymphadenectomy. J Urol 136(1):38–41

    PubMed  CAS  Google Scholar 

  • Mohs FE, Snow SN, Larson PO (1992) Mohs micrographic surgery for penile tumors. Urol Clin N Am 19(2):291–304

    CAS  Google Scholar 

  • Rando Sous A et al (2009) A review of penile cancer. Adv Urol 2009:415062. doi:10.1155/2009/415062

  • Rescigno P et al (2012) Combination of docetaxel and cetuximab for penile cancer: a case report and literature review. Anticancer Drugs 23(5):573–577

    Article  PubMed  CAS  Google Scholar 

  • Sonpavde G, Pagliaro LC et al (2013) Penile cancer: current therapy and future directions. Ann Oncol 24(5):1179–1189

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  • Stancik I, Holtl W (2003) Penile cancer: review of the recent literature. Curr Opin Urol 13(6):467–472

    Article  PubMed  Google Scholar 

  • Theodore C et al (2008) A phase II multicentre study of irinotecan (CPT 11) in combination with cisplatin (CDDP) in metastatic or locally advanced penile carcinoma (EORTC PROTOCOL 30992). Ann Oncol 19(7):1304–1307

    Article  PubMed  CAS  Google Scholar 

  • Therasse P et al (2000) New guidelines to evaluate the response to treatment in solid tumors. European organization for research and treatment of cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92(3):205–216

    Article  PubMed  CAS  Google Scholar 

  • Wein AJ et al (2007) Campbell-Walsh urology, 9th edn. Saunders Elsevier, Philadelphia, pp 1936–1937

    Google Scholar 

  • Yumura Y et al (2007) Neoadjuvant and adjuvant chemotherapy with methotrexate, cisplatin and bleomycin for advanced penile cancer: a case report. Hinyokika Kiyo 53(11):825–827

    PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by a project of large equipment sponsored by Bureau of Science and Technology in Shandong Province (2012SJGZ30).

Conflict of interest

We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, and there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in the manuscript entitled.

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Authors and Affiliations

  1. Department of Urology, Qilu Hospital, Shandong University, Jinan, 250012, China

    Benkui Zou, Zengchi Han & Zhonghua Xu

  2. Department of Urology, Tumor Hospital of Shandong Province, Jinan, 250117, China

    Benkui Zou, Jiasheng Bian, Jian Xu, Huansheng Wang & Mingshan Yang

  3. Shandong Academy of Medical Science, University of Jinan, Jinan, 250022, China

    Zhendan Wang & Fajun Pei

  4. Department of Hepatology, Tumor Hospital of Shandong Province, Shandong Academy of Medical Science, Jinan, 250022, China

    Sheng Li

Authors
  1. Benkui Zou
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  2. Zengchi Han
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  3. Zhendan Wang
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  4. Jiasheng Bian
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  5. Jian Xu
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  6. Huansheng Wang
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  7. Mingshan Yang
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  8. Fajun Pei
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  9. Sheng Li
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  10. Zhonghua Xu
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Corresponding authors

Correspondence to Sheng Li or Zhonghua Xu.

Additional information

Benkui Zou, Zengchi Han and Zhendan Wang have contributed equally to this work.

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Zou, B., Han, Z., Wang, Z. et al. Neoadjuvant therapy combined with a BMP regimen for treating penile cancer patients with lymph node metastasis: a retrospective study in China. J Cancer Res Clin Oncol 140, 1733–1738 (2014). https://doi.org/10.1007/s00432-014-1720-5

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  • DOI: https://doi.org/10.1007/s00432-014-1720-5

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