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Association of a single-nucleotide polymorphism from chromosome 17q12 with the aggressiveness of prostate cancer in a Hispanic population

  • Pablo A. Rojas
  • Verónica Torres-Estay
  • Javier Cerda-Infante
  • Viviana P. Montecinos
  • Javier Domínguez
  • José Arenas
  • Alejandro S. Godoy
  • Ignacio F. San FranciscoEmail author
Original Article - Cancer Research

Abstract

Purpose

To study the association between the polymorphisms, rs1859962 and rs4430796, from the chromosomes 17q24 and 17q12, respectively, with the risk of prostate cancer (PCa) and its clinical characteristics in a Hispanic (Chilean) population.

Methods

This study included 33 controls and 167 patients diagnosed with PCa. The polymorphisms, rs1859962 and rs4430796, were analyzed on blood specimens using quantitative PCR. The genetic analysis of the qPCR data was performed using the SNPStats program. A comparison between the clinical characteristics of the prostate cancers from the patients and the presence of the different polymorphism genotypes detected in blood specimens obtained from these patients was performed using the IBM SPSS v20.0 software.

Results

We observed no association of the SNPs and the risk of developing PCa (OR 0.84, 95 % CI 0.30–2.38, p = 1.0 to rs1859962 and OR 1.94, 95 % CI 0.57–6.52, p = 0.28 to rs4430796), both sporadic and hereditary. However, patients carrying the genotype G/G from the polymorphism rs4430796 had significantly higher PSA levels than patients carrying the other genotypes (15.05 ng/ml to G/G, 10 and 8.11 ng/ml to genotypes A/G y A/A, respectively, p = 0.01). Furthermore, patients with the genotype G/G of rs4430796 had higher tumor volume than other genotypes (9.45 cc to G/G and 5.22 cc to A/G + A/A, p = 0.04).

Conclusion

The polymorphism rs4430796 of the chromosome 17q12 appears to be a biomarker for cancer aggressiveness, increased PSA and tumor volume of PCa.

Keywords

17q12 17q24 rs4430796 Prostate cancer  Single-nucleotide polymorphism 

Notes

Acknowledgments

The authors thank the patients who participated in the study selflessly. The study was supported by FONDECYT No. 11110334.

Conflict of interest

The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Pablo A. Rojas
    • 1
  • Verónica Torres-Estay
    • 2
  • Javier Cerda-Infante
    • 3
  • Viviana P. Montecinos
    • 3
  • Javier Domínguez
    • 1
  • José Arenas
    • 4
  • Alejandro S. Godoy
    • 2
    • 5
  • Ignacio F. San Francisco
    • 1
    Email author
  1. 1.Departamento de Urología, Facultad de MedicinaPontificia Universidad Católica de ChileSantiagoChile
  2. 2.Departamento de Ciencias Fisiológicas, Facultad de Ciencias BiológicasPontificia Universidad Católica de ChileSantiagoChile
  3. 3.Departamento de Hemato-Oncología, Facultad de MedicinaPontificia Universidad Católica de ChileSantiagoChile
  4. 4.Servicio de UrologíaComplejo Asistencial Hospital Doctor Sótero del RíoSantiagoChile
  5. 5.Department of UrologyRoswell Park Cancer InstituteBuffaloUSA

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