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The importance of gender in patients with peritoneal metastases of appendiceal origin treated by cytoreduction and intraperitoneal chemotherapy: an analysis of 257 consecutive patients from an Australian centre

  • Original Article – Clinical Oncology
  • Published:
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Abstract

Background and objectives

In the setting of colorectal cancer, female gender has been associated with superior long-term outcomes. Our aim is to investigate the gender differences for metastatic epithelial neoplasms of the appendix treated by cytoreductive surgery (CS) and intraperitoneal chemotherapy (IPC).

Methods

The survival outcomes of patients treated with CS/IPC from 1996 to 2013 at St. George Hospital, Sydney, Australia, for peritoneal metastases of appendiceal origin were retrospectively analysed.

Results

Two hundred and fifty-seven consecutive patients were followed for a median of 35.3 months. Baseline characteristics between genders were comparable, including age (p = 0.13) and peritoneal cancer index (p = 0.94). Median overall survival (OS) and progression-free survival (PFS) was not reached (NR) and 44.4 months, with a 3-, 5- and 10-year survival of 82, 74 and 64 %. OS and PFS for females was NR and 50.7 months, compared to NR (p = 0.007) and 31.5 months for males (p = 0.07). Three-, 5- and 10-year survival rates for females were 88, 84 and 72 % compared to 74, 61 and 53 % for males.

Conclusion

Observed gender differences for neoplasms of the appendix may direct future research in gender-specific tumour markers and the development of adjuvant therapies to improve patient outcomes.

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Abbreviations

CRC:

Colorectal cancer

DPAM:

Diffuse peritoneal adenomucinosis

EPIC:

Early post-operative intraperitoneal chemotherapy

HIPEC:

Hyperthermic intraperitoneal chemotherapy

PCI:

Peritoneal cancer index

PMCA:

Peritoneal mucinous carcinomatosis

PMP:

Pseudomyxoma peritonei

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Acknowledgments

We would like to thank Dr. Jing Zhao for maintaining the on-site patient database at St. George Hospital, Sydney Australia.

Conflict of interest

Nothing to declare.

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Authors and Affiliations

  1. Hepatobiliary and Surgical Oncology Unit, UNSW Department of Surgery, St George Hospital, Kogarah, Sydney, NSW, 2217, Australia

    Lawson Ung, Terence C. Chua & David L. Morris

  2. St George Clinical School, University of New South Wales, Sydney, NSW, Australia

    Lawson Ung, Terence C. Chua & David L. Morris

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  1. Lawson Ung
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  2. Terence C. Chua
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  3. David L. Morris
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Correspondence to Terence C. Chua.

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Ung, L., Chua, T.C. & Morris, D.L. The importance of gender in patients with peritoneal metastases of appendiceal origin treated by cytoreduction and intraperitoneal chemotherapy: an analysis of 257 consecutive patients from an Australian centre. J Cancer Res Clin Oncol 140, 1037–1045 (2014). https://doi.org/10.1007/s00432-014-1633-3

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  • DOI: https://doi.org/10.1007/s00432-014-1633-3

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