Prophylactic bilateral salpingectomy (PBS) to reduce ovarian cancer risk incorporated in standard premenopausal hysterectomy: complications and re-operation rate

  • J. Vorwergk
  • M. P. Radosa
  • K. Nicolaus
  • N. Baus
  • J. Jimenez Cruz
  • M. Rengsberger
  • M. Gajda
  • H. Diebolder
  • I. B. RunnebaumEmail author
Original Article - Clinical Oncology



Hysterectomy for benign conditions can be combined with bilateral salpingectomy to prevent re-intervention for malignant or benign fallopian tube pathologies. The objective of this study was to evaluate the benefit of prophylactic bilateral salpingectomy (PBS) in standard hysterectomy in premenopausal women.


This retrospective cohort study included all premenopausal patients at our institution who underwent laparoscopically assisted vaginal hysterectomy (LAVH) without oophorectomy for benign pathologies between 2001 and 2007 [PBS group (LAVH + PBS), 2006–2007; non-PBS group (LAVH without PBS), 2001–2005]. Electronic and paper-based files as well as questionnaire responses were analyzed. In 2010, a survey on patients of a non-BRCA background with and without PBS was requested to complete a standardized questionnaire. Data were analyzed for differences between both subgroups regarding surgical outcome and adnexal pathologies as reported in the postoperative follow-up.


Surgical outcomes of 540 patients (PBS: 127; non-PBS: 413) revealed no difference between groups. No preneoplastic or malignant lesions were diagnosed in the fallopian tubes. Follow-up (non-PBS 92 months, PBS 55 months; p < 0.01) responses from 295 (54.6 %) patients showed a higher incidence of benign adnexal pathologies in the non-PBS group (26.9 vs. 13.9 %; p = 0.02). The rate of LAVH-related surgical re-intervention was higher in the non-PBS group (12.56 vs. 4.16 %; p = 0.04). No malignant neoplasm was reported in the cohort.


PBS did not increase the complication rate and reduced the incidence of adnexal pathologies requiring surgical re-intervention. Prospective trials should clarify the impact of PBS on cancer mortality.


Ovarian cancer Prophylactic salpingectomy Hysterectomy Risk-reducing bilateral salpingo-oophorectomy Premenopausal women 


Conflict of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • J. Vorwergk
    • 1
  • M. P. Radosa
    • 1
  • K. Nicolaus
    • 1
  • N. Baus
    • 1
  • J. Jimenez Cruz
    • 1
  • M. Rengsberger
    • 1
  • M. Gajda
    • 2
  • H. Diebolder
    • 1
  • I. B. Runnebaum
    • 1
    Email author
  1. 1.Department of Gynecology and Obstetrics, Jena University HospitalFriedrich Schiller UniversityJenaGermany
  2. 2.Department of PathologyJena University Hospital, Friedrich Schiller UniversityJenaGermany

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