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Dinner-to-bed time and post-dinner walk: new potential independent factors in esophageal cancer development

  • Qingxu Song
  • Hong Liu
  • Jianbo Wang
  • Yibin Jia
  • Yuan Liu
  • Nana Wang
  • Bingxu Tan
  • Shanghui Guan
  • Dianzheng An
  • Yufeng ChengEmail author
Original Article – Clinical Oncology

Abstract

Purpose

Esophageal squamous cell carcinoma (ESCC) remains a significant cause of morbidity and mortality worldwide. The aim of the study was to investigate the effects of shorter dinner-to-bed time and post-dinner walk on ESCC risk.

Methods

A matched case–control study with 232 ESCC patients and 286 age- and gender-matched healthy controls enrolled was conducted. Conditional logistic regression was used to calculated odds ratio (OR) and 95 % confidence intervals (95 % CI).

Results

The adjusted ORs of ESCC for subjects with shorter dinner-to-bed time (<3 h) were 2.84 (95 % CI 1.64–4.29), relative to those with longer dinner-to-bed time (≥4 h). While post-dinner walk was associated with a decreased ESCC risk (adjusted OR 0.64; 95 % CI 0.41–0.89). What’s more, when reflux symptom was added into the multivariate models, risk estimate for shorter dinner-to-bed time still remained statistically significant (p = 0.003), and risk estimate for post-dinner walk changed slightly. In the subgroup analysis stratified by post-dinner walk, subjects with shorter dinner-to-bed time experienced similar risk (adjusted ORs 2.71 vs. 2.82).

Conclusions

Shorter dinner-to-bed time is a potential risk factor for ESCC and post-dinner walk is a protective factor, providing evidence for the effect of lifestyle factors on ESCC risk.

Keywords

Dinner-to-bed time Post-dinner walk Carcinogenesis Esophageal squamous cell carcinoma 

Notes

Acknowledgments

The authors thank Dr. H. Tian (Department of Thoracic Surgery, Qilu Hospital of Shandong University) for subject recruitment. This work was supported by China Postdoctoral Science Fund (No. 2011M500531) and Science and Technology plan project of Shandong province (Grant No. 2012 GSF11852).

Conflict of interest

We declare that we have no conflict of interest.

Ethical standard

This study was approved by Qilu Hospital of Shandong University’s Ethics Review Committee and have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. All participants provided written informed consent.

References

  1. Avidan B, Sonnenberg A, Schnell TG, Sontag SJ (2001) Walking and chewing reduce postprandial acid reflux. Aliment Pharmacol Ther 15(2):151–155CrossRefPubMedGoogle Scholar
  2. Castellsague X, Munoz N, De Stefani E, Victora CG, Castelletto R, Rolon PA, Quintana MJ (1999) Independent and joint effects of tobacco smoking and alcohol drinking on the risk of esophageal cancer in men and women. Int J Cancer 82(5):657–664CrossRefPubMedGoogle Scholar
  3. Chen YJ, Chen C, Wu DC, Lee CH, Wu CI, Lee JM, Goan YG, Huang SP, Lin CC, Li TC, Chou YP, Wu MT (2006) Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase polymorphisms on esophageal cancer risks. Int J Cancer 119(12):2827–2831CrossRefPubMedGoogle Scholar
  4. Chen KH, Mukaisho K, Ling ZQ, Shimomura A, Sugihara H, Hattori T (2007) Association between duodenal contents reflux and squamous cell carcinoma–establishment of an esophageal cancer cell line derived from the metastatic tumor in a rat reflux model. Anticancer Res 27(1A):175–181PubMedGoogle Scholar
  5. Clark CS, Kraus BB, Sinclair J, Castell DO (1989) Gastroesophageal reflux induced by exercise in healthy volunteers. JAMA 261(24):3599–3601CrossRefPubMedGoogle Scholar
  6. Colditz GA, Sellers TA, Trapido E (2006) Epidemiology—identifying the causes and preventability of cancer? Nat Rev Cancer 6(1):75–83CrossRefPubMedGoogle Scholar
  7. Danaei G, Vander Hoorn S, Lopez AD, Murray CJ, Ezzati M (2005) Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet 366(9499):1784–1793CrossRefPubMedGoogle Scholar
  8. Dar NA, Shah IA, Bhat GA, Makhdoomi MA, Iqbal B, Rafiq R, Nisar I, Bhat AB, Nabi S, Masood A, Shah SA, Lone MM, Zargar SA, Islami F, Boffetta P (2013) Socioeconomic status and esophageal squamous cell carcinoma risk in Kashmir, India. Cancer Sci 104(9):1231–1236CrossRefPubMedGoogle Scholar
  9. Dodds WJ, Dent J, Hogan WJ, Helm JF, Hauser R, Patel GK, Egide MS (1982) Mechanisms of gastroesophageal reflux in patients with reflux esophagitis. N Engl J Med 307(25):1547–1552CrossRefPubMedGoogle Scholar
  10. Enzinger PC, Mayer RJ (2003) Esophageal cancer. N Engl J Med 349(23):2241–2252CrossRefPubMedGoogle Scholar
  11. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127(12):2893–2917CrossRefPubMedGoogle Scholar
  12. Fujiwara Y, Machida A, Watanabe Y, Shiba M, Tominaga K, Watanabe T, Oshitani N, Higuchi K, Arakawa T (2005) Association between dinner-to-bed time and gastro-esophageal reflux disease. Am J Gastroenterol 100(12):2633–2636CrossRefPubMedGoogle Scholar
  13. Gao Y, Hu N, Han XY, Ding T, Giffen C, Goldstein AM, Taylor PR (2011) Risk factors for esophageal and gastric cancers in Shanxi Province, China: a case–control study. Cancer Epidemiol 35(6):e91–e99CrossRefPubMedPubMedCentralGoogle Scholar
  14. Hung HC, Huang MC, Lee JM, Wu DC, Hsu HK, Wu MT (2004) Association between diet and esophageal cancer in Taiwan. J Gastroenterol Hepatol 19(6):632–637CrossRefPubMedGoogle Scholar
  15. Leitzmann MF, Koebnick C, Freedman ND, Park Y, Ballard-Barbash R, Hollenbeck A, Schatzkin A, Abnet CC (2009) Physical activity and esophageal and gastric carcinoma in a large prospective study. Am J Prev Med 36(2):112–119CrossRefPubMedGoogle Scholar
  16. Ling ZQ, Mukaisho K, Yamamoto H, Chen KH, Asano S, Araki Y, Sugihara H, Mao WM, Hattori T (2010) Initiation of malignancy by duodenal contents reflux and the role of ezrin in developing esophageal squamous cell carcinoma. Cancer Sci 101(3):624–630CrossRefPubMedGoogle Scholar
  17. Meining A, Classen M (2000) The role of diet and lifestyle measures in the pathogenesis and treatment of gastroesophageal reflux disease. Am J Gastroenterol 95(10):2692–2697CrossRefPubMedGoogle Scholar
  18. Parent ME, Rousseau MC, El-Zein M, Latreille B, Desy M, Siemiatycki J (2011) Occupational and recreational physical activity during adult life and the risk of cancer among men. Cancer Epidemiol 35(2):151–159CrossRefPubMedGoogle Scholar
  19. Piesman M, Hwang I, Maydonovitch C, Wong RK (2007) Nocturnal reflux episodes following the administration of a standardized meal. Does timing matter? Am J Gastroenterol 102(10):2128–2134CrossRefPubMedGoogle Scholar
  20. Schweigert M, Dubecz A, Stein HJ (2013) Oesophageal cancer—an overview. Nat Rev Gastroenterol Hepatol 10(4):230–244CrossRefPubMedGoogle Scholar
  21. Sifrim D, Holloway R, Silny J, Tack J, Lerut A, Janssens J (2001) Composition of the postprandial refluxate in patients with gastroesophageal reflux disease. Am J Gastroenterol 96(3):647–655CrossRefPubMedGoogle Scholar
  22. Uno K, Iijima K, Hatta W, Koike T, Abe Y, Asano N, Kusaka G, Shimosegawa T (2011) Direct measurement of gastroesophageal reflux episodes in patients with squamous cell carcinoma by 24-h pH-impedance monitoring. Am J Gastroenterol 106(11):1923–1929CrossRefPubMedGoogle Scholar
  23. Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101(8):1900–1920; quiz 1943CrossRefPubMedGoogle Scholar
  24. Vela MF, Tutuian R, Katz PO, Castell DO (2003) Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured by combined multichannel intraluminal impedance and pH. Aliment Pharmacol Ther 17(2):243–251CrossRefPubMedGoogle Scholar
  25. Wang Z, Tang L, Sun G, Tang Y, Xie Y, Wang S, Hu X, Gao W, Cox SB, Wang JS (2006) Etiological study of esophageal squamous cell carcinoma in an endemic region: a population-based case control study in Huaian, China. BMC Cancer 6:287CrossRefPubMedPubMedCentralGoogle Scholar
  26. Wang JB, Fan JH, Liang H, Li J, Xiao HJ, Wei WQ, Dawsey SM, Qiao YL, Boffetta P (2012) Attributable causes of esophageal cancer incidence and mortality in China. PLoS One 7(8):e42281CrossRefPubMedPubMedCentralGoogle Scholar
  27. Wildi SM, Tutuian R, Castell DO (2004) The influence of rapid food intake on postprandial reflux: studies in healthy volunteers. Am J Gastroenterol 99(9):1645–1651CrossRefPubMedGoogle Scholar
  28. Zheng Z, Nordenstedt H, Pedersen NL, Lagergren J, Ye W (2007) Lifestyle factors and risk for symptomatic gastroesophageal reflux in monozygotic twins. Gastroenterology 132(1):87–95CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Qingxu Song
    • 1
  • Hong Liu
    • 1
  • Jianbo Wang
    • 1
  • Yibin Jia
    • 1
  • Yuan Liu
    • 1
  • Nana Wang
    • 1
  • Bingxu Tan
    • 1
  • Shanghui Guan
    • 1
  • Dianzheng An
    • 1
  • Yufeng Cheng
    • 1
    Email author
  1. 1.Department of Radiation Oncology, Qilu HospitalShandong UniversityJinanPeople’s Republic of China

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