Skip to main content

Advertisement

SpringerLink
Log in

Effect of neoadjuvant treatment in the management of osteosarcomas of the head and neck

  • Original Paper
  • Published:
Journal of Cancer Research and Clinical Oncology Aims and scope Submit manuscript

Abstract

Purpose

Osteosarcomas of the craniomaxillofacial region in adults are rare malignant tumors with many sites of origin. The purpose of this study was to analyze the outcome of adult patients suffering from osteosarcomas and investigate whether neoadjuvant chemotherapy would be beneficial to overall outcome.

Patients and methods

The medical records of 36 patients treated during 2002–2012 were reviewed. All patients suffered from primary osteosarcomas of the craniomaxillofacial region.

Results

The mean survival of patients was 64.49 ± 23.52 months. The 2- and 5-year overall survival rates in the neoadjuvant treatment group were 100 and 66.7 %; in the surgery only group, the overall survival rates were 66.7 and 41.7 %, respectively. The neoadjuvant treatment (p = 0.017), tumor size (p = 0.004), tumor location (p = 0.02), and age (p < 0.0001) were significant parameters influencing survival, whereas other tumor-related or demographic factors had no significant influence on survival.

Conclusions

Early identification of osteosarcoma of the craniomaxillofacial region and combined treatment by neoadjuvant chemotherapy with radical surgery are the most important strategies in dealing with these sarcomas. If possible, this treatment option should be followed unless contraindicated by other factors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  • Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A, Picci P (2006) Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer 106(5):1154–1161

    Article  PubMed  Google Scholar 

  • Bentz BG, Singh B, Woodruff J, Brennan M, Shah JP, Kraus D (2004) Head and neck soft tissue sarcomas: a multivariate analysis of outcomes. Ann Surg Oncol 11(6):619–628

    Article  PubMed  Google Scholar 

  • Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K et al (2002) Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 20(3):776–790

    Article  PubMed  Google Scholar 

  • Carrle D, Bielack SS (2006) Current strategies of chemotherapy in osteosarcoma. Int Orthop 30(6):445–451

    Article  PubMed Central  PubMed  Google Scholar 

  • Chidzonga MM, Mahomva L (2007) Sarcomas of the oral and maxillofacial region: a review of 88 cases in Zimbabwe. Br J Oral Maxillofac Surg 45(4):317–318

    Article  CAS  PubMed  Google Scholar 

  • Clark JL, Unni KK, Dahlin DC, Devine KD (1983) Osteosarcoma of the jaw. Cancer 51(12):2311–2316

    Article  CAS  PubMed  Google Scholar 

  • Davis AM, Bell RS, Goodwin PJ (1994) Prognostic factors in osteosarcoma: a critical review. J Clin Oncol 12(2):423–431

    CAS  PubMed  Google Scholar 

  • Jasnau S, Meyer U, Potratz J, Jundt G, Kevric M, Joos UK et al (2008a) Craniofacial osteosarcoma experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol 44(3):286–294

    Article  PubMed  Google Scholar 

  • Jasnau S, Meyer U, Potratz J, Jundt G, Kevric M, Joos UK et al (2008b) Craniofacial osteosarcoma Experience of the cooperative German-Austrian-Swiss osteosarcoma study group. Oral Oncol 44(3):286–294

    Article  PubMed  Google Scholar 

  • Klein MJ, Siegal GP (2006) Osteosarcoma: anatomic and histologic variants. Am J Clin Pathol 125(4):555–581

    PubMed  Google Scholar 

  • Link MP, Goorin AM, Miser AW, Green AA, Pratt CB, Belasco JB et al (1986) The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. N Engl J Med 314(25):1600–1606

    Article  CAS  PubMed  Google Scholar 

  • Miwa S, Takeuchi A, Shirai T, Taki J, Yamamoto N, Nishida H et al (2013) Prognostic value of radiological response to chemotherapy in patients with osteosarcoma. PLoS ONE 8(7):e70015

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Mücke T, Mitchell DA, Tannapfel A, Hölzle F, Kesting MR, Wolff KD et al (2010) Outcome in adult patients with head and neck sarcomas—a 10-year analysis. J Surg Oncol 102(2):170–174

    Article  PubMed  Google Scholar 

  • Pellitteri PK, Ferlito A, Bradley PJ, Shaha AR, Rinaldo A (2003) Management of sarcomas of the head and neck in adults. Oral Oncol 39(1):2–12

    Article  PubMed  Google Scholar 

  • Salzer-Kuntschik M, Delling G, Beron G, Sigmund R (1983) Morphological grades of regression in osteosarcoma after polychemotherapy—study COSS 80. J Cancer Res Clin Oncol 106(Suppl):21–24

    Article  PubMed  Google Scholar 

  • Smeele LE, Kostense PJ, van der Waal I, Snow GB (1997) Effect of chemotherapy on survival of craniofacial osteosarcoma: a systematic review of 201 patients. J Clin Oncol 15(1):363–367

    CAS  PubMed  Google Scholar 

  • Thiele OC, Freier K, Bacon C, Egerer G, Hofele CM (2008) Interdisciplinary combined treatment of craniofacial osteosarcoma with neoadjuvant and adjuvant chemotherapy and excision of the tumour: a retrospective study. Br J Oral Maxillofac Surg 46(7):533–536

    Article  PubMed  Google Scholar 

  • Winkler K, Bielack SS, Delling G, Jurgens H, Kotz R, Salzer-Kuntschik M (1993) Treatment of osteosarcoma: experience of the Cooperative Osteosarcoma Study Group (COSS). Cancer Treat Res 62:269–277

    CAS  PubMed  Google Scholar 

Download references

Conflict of interest

The authors have no conflict of interest to declare.

Author information

Authors and Affiliations

  1. Department of Oral and Maxillofacial Surgery, Technische Universität München, Klinikum Rechts der Isar, Ismaninger Str. 22, 81675, Munich, Germany

    Thomas Mücke, Klaus-Dietrich Wolff & Denys John Loeffelbein

  2. Oral and Facial Specialties Department, Pinderfields General Hospital, Aberford Road, Wakefield, WF1 4DG, UK

    Thomas Mücke, David A. Mitchell & Anastasios Kanatas

  3. Institute of Pathology, Ruhr University of Bochum, Bochum, Germany

    Andrea Tannapfel

Authors
  1. Thomas Mücke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. David A. Mitchell
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andrea Tannapfel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Klaus-Dietrich Wolff
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Denys John Loeffelbein
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Anastasios Kanatas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Thomas Mücke.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mücke, T., Mitchell, D.A., Tannapfel, A. et al. Effect of neoadjuvant treatment in the management of osteosarcomas of the head and neck. J Cancer Res Clin Oncol 140, 127–131 (2014). https://doi.org/10.1007/s00432-013-1550-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00432-013-1550-x

Keywords

Search

Navigation