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Histopathology of surgically treated renal tumours in young adults: a developing country perspective

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Abstract

Background

There is no data on the histopathological characteristics of renal tumours in young adults in Pakistan.

Materials and methods

We retrospectively analysed 133 young adults (age: 16 to ≤40 years) who underwent nephrectomy for suspected renal cancer from 1994 till July 2010. The demographical and pathological parameters were determined from original surgical biopsy reports and case files, and analysed.

Results

The mean age of patients was 33.3 ± 6.2 years. Overall, 121 (88.9%) renal tumours were malignant, and 15 (11%) benign. Among malignant tumours, renal cell carcinoma (RCC) was predominant (100/121; 82.6%). The subtypes of RCC included: clear cell RCC, 84 (84%); papillary RCC, 11 (11%), chromophobe RCC, 3 (3%) and sarcomatoid RCC, 2 (2%). Other malignant tumours included: transitional cell carcinoma (9/121; 7.4%), primitive neuroectodermal tumour (5/121; 4.1%), synovial sarcoma (2/121; 1.6%), Non-Hodgkin’s lymphoma (2/121; 1.6%), leiomyosarcoma (1/121; 0.8%), malignant fibrous histiocytoma (1/121; 0.8%) and squamous cell carcinoma (1/121; 0.8%). Among benign tumours, there were 11 cases of angiomyolipoma (11/15; 73.3%), three cases of oncocytoma (3/15; 20%) and one case of schwannoma (1/15; 6.6%). Almost two-third (62.7%) patients had stage I/II tumours, 22 (18.1%) stage III and 23 (19%) stage IV disease at the time of surgery.

Conclusion

A wide variety of renal tumours is documented in young adults with large size of the tumours and late presentation in our population.

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Authors and Affiliations

  1. Histopathology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, 74200, Pakistan

    Muhammed Mubarak & Javed I. Kazi

  2. Urology Department, Sindh Institute of Urology and Transplantation (SIUT), Karachi, Pakistan

    Rehan Mohsin, Altaf Hashmi, Syed Ali Anwer Naqvi & Syed Adeeb ul Hassan Rizvi

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  1. Muhammed Mubarak
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  2. Javed I. Kazi
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  3. Rehan Mohsin
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  4. Altaf Hashmi
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  5. Syed Ali Anwer Naqvi
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  6. Syed Adeeb ul Hassan Rizvi
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Correspondence to Muhammed Mubarak.

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Mubarak, M., Kazi, J.I., Mohsin, R. et al. Histopathology of surgically treated renal tumours in young adults: a developing country perspective. J Cancer Res Clin Oncol 138, 189–194 (2012). https://doi.org/10.1007/s00432-011-1082-1

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  • DOI: https://doi.org/10.1007/s00432-011-1082-1

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