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Diabetes mellitus negatively impacts survival of patients with colon cancer, particularly in stage II disease

Journal of Cancer Research and Clinical Oncology volume 137, pages 211–220 (2011)Cite this article

Abstract

Purpose

This retrospective study aimed to determine the effects of diabetes on overall survival (OS) and cancer-specific survival (CSS) in patients with newly diagnosed colon cancers, with particular focus on the impact of diabetes on survival at each stage of colon cancer.

Methods

From January 1999 to January 2008, 2762 consecutive patients diagnosed with colon cancer in Taipei Veterans General Hospital were enrolled. The general characteristics as well as presence of diabetes prior to colon cancer diagnosis were identified. Cox proportional hazard analyses were used for prognostic factors determination; and survival was analyzed using the Kaplan–Meier method with log-rank test.

Results

A total of 469 patients (17%) had diabetes at diagnosis of colon cancer. Patients with diabetes had baseline characteristics comparable to those without diabetes with the exception that the patients with diabetes were older (>65 years). Diabetes significantly and negatively impacted OS and CSS in multivariate analyses. After adjusting for possible confounding factors, the prognostic impact of diabetes on OS and CSS was particularly significant in patients with stage II colon cancer.

Conclusions

Diabetes is a poor prognostic factor in patients with newly diagnosed colon cancer, and it may directly impact the tumor behavior of stage II disease. Further study is required to elucidate the underlying pathophysiologic mechanisms.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Author information

Affiliations

  1. Division of Hematology-Oncology, Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei, 112, Taiwan

    Yu-Chung Huang, Chun-Yu Liu & Hao-Wei Teng

  2. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

    Hao-Wei Teng

  3. School of Medicine, National Yang-Ming University, Taipei, Taiwan

    Yu-Chung Huang, Chun-Yu Liu & Hao-Wei Teng

  4. Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan

    Jen-Kou Lin, Wei-Shone Chen, Tzu-Chen Lin, Shung-Haur Yang, Jeng-Kai Jiang, Shih-Ching Chang, Yuan-Tzu Lan & Huann-Sheng Wang

  5. Division of Biostatistics, Institute of Public Health, National Yang-Ming University, Taipei, Taiwan

    Ya-Wen Yang

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  1. Yu-Chung Huang
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  2. Jen-Kou Lin
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Correspondence to Hao-Wei Teng.

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Huang, YC., Lin, JK., Chen, WS. et al. Diabetes mellitus negatively impacts survival of patients with colon cancer, particularly in stage II disease. J Cancer Res Clin Oncol 137, 211–220 (2011). https://doi.org/10.1007/s00432-010-0879-7

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  • DOI: https://doi.org/10.1007/s00432-010-0879-7

Keywords

  • Cancer-specific survival
  • Colon cancer
  • Diabetes mellitus
  • Stage II
  • Prognosis