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Microwave ablation treatment of liver cancer with 2,450-MHz cooled-shaft antenna: an experimental and clinical study

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Abstract

Purpose

To evaluate effects of microwave ablation with a 2,450-MHz internally cooled-shaft antenna in animal experiments and in a clinical study.

Methods

Microwave ablation was performed using a cooled-shaft antenna in eight in vivo (36 ablations) porcine livers. The coagulation diameters achieved in different microwave ablation parameter groups were compared. Sixty patients (44 men, 16 women; mean age 53 years) with 96, 1–8 cm (mean 3.20 ± 0.17 cm) liver cancers were treated with the same microwave ablation technique. Complete ablation (CA), local tumor progression (LTP) rates and complications were determined.

Results

In vivo livers, short axis diameter correlated with the coagulation duration in a sigmoidal curve fashion (60-W group R 2 = 0.76, 80-W group R 2 = 0.87), with a relative plateau achieved within 10 min for power settings of 60 or 80 W. Within 10 min in the 60 and 80-W groups, respectively, 89 and 85.76% of maximum short axis diameter were achieved. CA rates in small (3.0 cm), intermediate (3.1–5.0 cm) and large (5.1–8.0 cm) liver cancers were 96.43% (54/56), 92.31% (24/26) and 78.57% (11/14), respectively. During a mean follow-up period of 17.17 ± 6.52 months, LTP occurred in five (5.21%) treated cancers. There was no significant difference in the CA and LTP rate between the HCC and liver metastasis patient subgroups (P > 0.05).

Conclusions

The short axis diameter enlargement has a relative plateau within 10 min by fixing power output to 60 or 80 W, using the 2,450-MHz internally cooled-shaft antenna in vivo porcine livers. Effective local tumor control was achieved during one microwave ablation session.

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Acknowledgments

This study was supported by a grant of Sciences and Technology Committee of Guangdong Province (No. 2006B35802009), China and Sciences and Technology Committee of Guangzhou City, China (No. 2007Z3-E0231).

Conflict of interest statement

None.

Author information

Authors and Affiliations

  1. Department of Medical Imaging and Interventional Radiology, Cancer Center and State Key Laboratory of Oncology in South China, Sun Yat-sen University, 651 Dongfeng Road, East, Guangzhou, 510060, Guangdong, People’s Republic of China

    Dechao Jiao, Fujun Zhang, Chuanxing Li, Zilin Huang, Liang Zhang, Weidong Zhang, Peihong Wu, Guangfeng Duan & Jianjun Han

  2. Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Research Institute of Interventional Radiology of Zhengzhou University, Zhengzhou, 450052, People’s Republic of China

    Dechao Jiao & Xinwei Han

  3. Department of Diagnostic Ultrasound, Beijing Friendship Hospital Affiliated of Capital Medical University, Beijing, 100050, People’s Republic of China

    Linxue Qian

  4. School of Biotechnology, Southern Medical University, Guangzhou, 510515, People’s Republic of China

    Yanling Zhang

Authors
  1. Dechao Jiao
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  2. Linxue Qian
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  3. Yanling Zhang
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  4. Fujun Zhang
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  5. Chuanxing Li
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  6. Zilin Huang
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  7. Liang Zhang
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  8. Weidong Zhang
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  9. Peihong Wu
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  10. Xinwei Han
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  11. Guangfeng Duan
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  12. Jianjun Han
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Corresponding authors

Correspondence to Fujun Zhang or Chuanxing Li.

Additional information

D. Jiao, L. Qian and Y. Zhang contributed equally to this work.

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Jiao, D., Qian, L., Zhang, Y. et al. Microwave ablation treatment of liver cancer with 2,450-MHz cooled-shaft antenna: an experimental and clinical study. J Cancer Res Clin Oncol 136, 1507–1516 (2010). https://doi.org/10.1007/s00432-010-0808-9

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  • DOI: https://doi.org/10.1007/s00432-010-0808-9

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