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XPC gene variants: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy

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Abstract

Purpose

To investigate the association between two Xeroderma pigmentosum group C polymorphism (XPC Lys939Gln and insertion/deletion PAT −/+ in intron 9) and bladder cancer (BC) susceptibility.

Materials and methods

Genotyping was performed in 208 BC patients and 245 controls by PCR–RFLP method.

Results

XPC PAT +/+ genotype was associated with elevated risk of BC (p = 0.021, OR = 2.49). XPC Lys939Gln AC + CC genotype was significantly associated with risk in invasive stage of BC (p = 0.041, OR = 2.52). Haplotype analysis revealed that variant genotypes C of XPC Lys939Gln and + of PAT, C+ were significantly associated with risk of BC (p = 0.004, OR = 1.70). The CC genotype of Lys939Gln was associated with high risk for recurrence in BCG-treated patients (HR = 3.21, p = 0.036) thus, showing reduced recurrence-free survival (AC + CC/AA = 36/60 months; log rank p = 0.045).

Conclusion

Polymorphisms and haplotypes in XPC appear to influence susceptibility to BC risk. The variant C allele at Lys939Gln may be responsible for early recurrence in BCG-treated patients.

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Abbreviations

XPC :

Xeroderma pigmentosum group C

BCG:

Bacillus Calmette–Guerin

BC:

Bladder cancer

MMC:

Mitomycin-C

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Acknowledgments

The study was supported by the grant of Department of Science and Technology, New Delhi Govt. of India. RG is thankful to Council of Scientific and Industrial Research, New Delhi for JRF.

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Authors and Affiliations

  1. Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGIMS), Raebareli Road, Lucknow, Uttar Pradesh, 226014, India

    Ruchika Gangwar, Anil Mandhani & Rama Devi Mittal

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  1. Ruchika Gangwar
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  2. Anil Mandhani
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  3. Rama Devi Mittal
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Correspondence to Rama Devi Mittal.

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Gangwar, R., Mandhani, A. & Mittal, R.D. XPC gene variants: a risk factor for recurrence of urothelial bladder carcinoma in patients on BCG immunotherapy. J Cancer Res Clin Oncol 136, 779–786 (2010). https://doi.org/10.1007/s00432-009-0717-y

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  • DOI: https://doi.org/10.1007/s00432-009-0717-y

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