Abstract
Purpose
The aim of this study was to examine trends in clinicopathological characteristics of renal cell carcinoma (RCC) cases at presentation in a single institution over a 25-years period.
Patients and methods
The medical files of 505 patients with histologically confirmed primary RCC from 1981 to 2006 were retrospectively reviewed. Host and tumor characteristics at presentation were compared following stratification by hospitalization period (1981–1990, 1991–2000, and 2001–2006).
Results
Age at presentation did not change significantly over time. The incidentally diagnosed cases increased significantly by time (10.2, 40.5, 62.7%), in proportion to small (<4 cm) tumors (8.6, 17.3, 30.6%), while tumor diameter decreased significantly (8.5 ± 3.8, 7.4 ± 3.5, 5.8 ± 2.9). The rate of organ-confined tumors increased significantly (42.1, 63.6, 68.9%), followed by a less pronounced decrease of metastatic cases (12.3, 8.9, 6.8%).
Conclusions
The evolution of tumor characteristics at presentation in a single institution is apparent within the last 25 years. Major changes were noticed within organ-confined and small tumors and call for familiarization of urologists with nephron-sparing techniques and novel ablation technologies.
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References
Armitage P, Berry G (1987) Statistical methods in medical research, 2nd edn. Blackwell Scientific Publications, Oxford
Chow WH, Devesa SS, Warren JL, Fraumeni JF Jr (1999) The rising incidence of renal cell cancer in the United States. JAMA 281:1628–1631. doi:10.1001/jama.281.17.1628
Frank I, Blute ML, Cheville JC, Lohse CM, Weaver AL, Zincke H (2003) Solid renal tumors: an analysis of pathological features related to tumor size. J Urol 170:2217–2220. doi:10.1097/01.ju.0000095475.12515.5e
Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6:655–663. doi:10.1097/00000478-198210000-00007
Gudbjartsson T, Thoroddsen A, Petursdottir V, Hardarson S, Magnusson J, Einarsson GV (2005) Effect of incidental detection for survival of patients with renal cell carcinoma: results of population-based study of 701 patients. Urology 66:1186–1191. doi:10.1016/j.urology.2005.07.009
Jemal A, Siegel R, Ward E, Murray T, Xu J, Smigal C et al (2006) Cancer statistics, 2006. CA Cancer J Clin 56:106–130
Kummerlin L, Ten Kate F, Wijkstra H, de la Rosette J, Laguna P (2006) Renal cell carcinoma in the Netherlands: difference in stage presentation in the last decade. Eur Urol Suppl 5:106. doi:10.1016/S1569-9056(06)60341-2
Lee CT, Katz J, Shi W, Thaler HT, Reuter VE, Russo P (2000) Surgical management of renal tumors 4 cm or less in a contemporary cohort. J Urol 163:730–736. doi:10.1016/S0022-5347(05)67793-2
Ljungberg B, Hanbury DC, Kuczyk MA, Merseburger AS, Mulders PFA, Patard J-J et al (2007) Renal cell carcinoma guideline. Eur Urol 51:1502–1510. doi:10.1016/j.eururo.2007.03.035
Luciani LG, Cestari R, Tallarigo C (2000) Incidental renal cell carcinoma-age and stage characterization and clinical implications: study of 1092 patients (1982–1997). Urology 56:58–62. doi:10.1016/S0090-4295(00)00534-3
Mathew A, Devesa SS, Fraumeni JF Jr, Chow WH (2002) Global increases in kidney cancer incidence, 1973–1992. Eur J Cancer Prev 11:171–178. doi:10.1097/00008469-200204000-00010
Murai M, Oya M (2004) Renal cell carcinoma: etiology, incidence and epidemiology. Curr Opin Urol 14:229–233. doi:10.1097/01.mou.0000135078.04721.f5
Nguyen MM, Gill IS, Ellison LM (2006) The evolving presentation of renal carcinoma in the United States: trends from the Surveillance, Epidemiology, and End Results program. J Urol 176:2397–2400. doi:10.1016/j.juro.2006.07.144
Pantuck AJ, Zisman A, Belldegrun AS (2001) The changing natural history of renal cell carcinoma. J Urol 166:1611–1623. doi:10.1016/S0022-5347(05)65640-6
Parkin DM, Bray F, Ferlay J, Pisani P (2005) Global cancer statistics, 2002. CA Cancer J Clin 55:74–108
Patard J-J, Tazi H, Bensalah K, Rodriguez A, Vincendeau S, Rioux-Leclercq N et al (2004) The changing evolution of renal tumours: a single center experience over a two-decade period. Eur Urol 45:490–494. doi:10.1016/j.eururo.2003.12.015
Permpongkosol S, Bagga HS, Romero FR, Solomon SB, Kavoussi LR (2006) Trends in the operative management of renal tumours over a 14-year period. BJU Int 98:751–755. doi:10.1111/j.1464-410X.2006.06391.x
Ries LA, Eisner MP, Kosary CL et al (2000) SEER Cancer Statistics Review, 1973–1997. National Cancer Institute, Bethesda, Maryland
Rini BI, Campbell SC, Rathmell WK (2006) Renal cell carcinoma. Curr Opin Oncol 18:289–296. doi:10.1097/01.cco.0000219260.60714.c4
Robson CJ, Churchill BM, Anderson W (1969) The results of radical nephrectomy for renal cell carcinoma. J Urol 101:297–301
Sobin LH, Wittekind C (2003) TNM classifications: kidney. In: TNM classifications of malignant tumours, 6th edn, Wiley, New York, pp 193–195
Storkel S, Eble JN, Adlakha K, Amin M, Blute ML, Bostwick DG et al (1997) Classification of renal cell carcinoma: Workgroup No 1. Union Internationale Contre le Cancer (UICC) and American Joint Committee on Cancer (AJCC). Cancer 80:987–989. doi:10.1002/(SICI)1097-0142(19970901)80:5≤987::AID-CNCR24≥3.0.CO;2-R
Taccoen X, Valeri A, Descotes J-L, Morin V, Stindel E, Doucet L, Joulin V, Bocqueraz F, Coulange C, Rambeaud J-J, Fournier G, Mejean A, the Oncology Committee of the Association Francaise d’Urologie (2007) Renal cell carcinoma in adults 40 years old or less: young age is an independent prognostic factor for cancer-specific survival. Eur Urol 51:980–987. doi:10.1016/j.eururo.2006.10.025
Wunderlich H, Schumann S, Jantitzky V, Moravek P, Podhola M, Kosmehl H et al (1998) Increase of renal cell carcinoma incidence in central Europe. Eur Urol 33:538–541. doi:10.1159/000019652
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Mitropoulos, D., Petrolekas, A., Anastasiou, I. et al. Differences in presentation characteristics of renal cell carcinoma in the last 25 years: a single center experience. J Cancer Res Clin Oncol 134, 1297–1301 (2008). https://doi.org/10.1007/s00432-008-0420-4
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DOI: https://doi.org/10.1007/s00432-008-0420-4