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Journal of Cancer Research and Clinical Oncology

, Volume 133, Issue 11, pp 897–901 | Cite as

Anti-vascular endothelial growth factor antibody bevacizumab in conjunction with chemotherapy in metastasising melanoma

  • Patrick TerheydenEmail author
  • Maja Ann Hofmann
  • M. Weininger
  • Eva-B. Bröcker
  • Jürgen C. Becker
Letter to the Editor

Abstract

Purpose

The combination of the antiangiogenic antibody bevacizumab with standard chemotherapy has improved the prognosis in patients with metastastic colorectal cancer and other advanced cancers. The role of combined anti-VEGF and chemotherapy in metastastic melanoma is just starting to be elucidated.

Methods

We tested this notion in three patients with advanced and therapy-refractory melanoma.

Results

Interestingly, two patients achieved objective regressions after three courses of therapy; the third patient, albeit progressing demonstrated a pronounced liquid necrosis in bulky lymphnode metastasis.

Conclusion

Further studies are warranted to scrutinise these impressive therapeutic effects on the combination of bevacizumab and chemotherapy in melanoma.

Keywords

Melanoma Metastases Therapy Angiogenesis Chemotherapy 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Patrick Terheyden
    • 1
    Email author
  • Maja Ann Hofmann
    • 2
  • M. Weininger
    • 3
  • Eva-B. Bröcker
    • 1
  • Jürgen C. Becker
    • 1
  1. 1.Department of Dermatology, Venerology and AllergologyUniversity of WürzburgWürzburgGermany
  2. 2.Department of Dermatology and AllergyCharité, Universitätsmedizin BerlinBerlinGermany
  3. 3.Department of RadiologyUniversity of WürzburgWürzburgGermany

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