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Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumors

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Abstract

Purpose

Only few immunohistochemical markers besides c-kit exist for gastrointestinal stromal tumors (GISTs). Thy-1, a cell-surface glycoprotein, is a marker for several types of stem cells and particularly for neuronal precursor cells. The aim of this study was to determine Thy-1 expression in GISTs.

Materials and methods

Fifty-seven surgically resected and paraffin-embedded GIST samples were analyzed by immunohistochemistry with peroxidase method for Thy-1 molecule.

Results

Thy-1 was detected in the majority of 57 GIST samples (54 out of 57 patients, 95%). All samples were c-kit positive and 90% were CD34 positive. All three Thy-1 negative samples were CD34 positive, had a low proliferative index (Ki-67 ≤ 10%) and were located in the upper gastrointestinal tract (one in esophagus and two in the stomach). As a tendency, Thy-1 negative patients had a better prognosis, although not reaching level of significance due to low numbers.

Conclusions

Thy-1 is expressed in the majority of GISTs, suggesting a novel, additional standard marker for identifying GIST. Future studies should focus on the role of Thy-1 in the pathogenesis of GIST and subsequently on its potential to act as a molecular target for adjuvant therapy with new molecular antitumor agents.

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Acknowledgment

We thank Beate Roth for excellent technical assistance.

Author information

Authors and Affiliations

  1. Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany

    Despoina Oikonomou, Kambiz Hassan, Jussuf T. Kaifi, Paulus G. Schurr, Emre F. Yekebas, Oliver Mann, Tim Strate & Jakob R. Izbicki

  2. Department of Pediatric Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Henning C. Fiegel & Dietrich Kluth

  3. Institute for Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany

    Uta Reichelt

  4. Department of Surgery, Kagoshima University, Kagoshima, Japan

    Kuniaki Aridome

Authors
  1. Despoina Oikonomou
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  2. Kambiz Hassan
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  3. Jussuf T. Kaifi
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  4. Henning C. Fiegel
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  5. Paulus G. Schurr
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  6. Uta Reichelt
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  7. Kuniaki Aridome
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  8. Emre F. Yekebas
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  9. Oliver Mann
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  10. Dietrich Kluth
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  11. Tim Strate
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  12. Jakob R. Izbicki
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Corresponding author

Correspondence to Despoina Oikonomou.

Additional information

Financial support for this study was provided by research grants from the Hamburger Krebsgesellschaft e. V. (J.T.K., E.F.Y., J.R.I.).

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Oikonomou, D., Hassan, K., Kaifi, J.T. et al. Thy-1 as a potential novel diagnostic marker for gastrointestinal stromal tumors. J Cancer Res Clin Oncol 133, 951–955 (2007). https://doi.org/10.1007/s00432-007-0238-5

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  • DOI: https://doi.org/10.1007/s00432-007-0238-5

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