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Journal of Cancer Research and Clinical Oncology

, Volume 133, Issue 11, pp 841–846 | Cite as

Combination therapy of S-1 and CDDP for patients with colorectal cancer

  • Kazumi UchidaEmail author
  • Kazuhiko Hayashi
  • Hidekazu Kuramochi
  • Go Nakajima
  • Yuji Inoue
  • Masakazu Yamamoto
Original Paper

Abstract

Purpose

We evaluate the feasibility and efficacy of S-1 in combination with cisplatin (CDDP) for patients with colorectal cancer.

Methods

A total of 52 patients with advanced or recurrent colorectal cancer were included. S-1 was given orally twice daily for 21 days and CDDP 30 mg/m2 on day 1 and 8, followed by a 2-week period of no treatment.

Results

Tumor responses among patients included 18 PR, 12 SD, and 16 PD (n = 46). The overall response rate was 36.4% (18/46). The response rate of the patients with prior chemotherapy was 22.2% (4/18) and 50.0% (12/24) among the patients who had no prior therapy. The median survival periods were 555 days and the median progression free survival periods were 183 days, respectively. S-1 in combination with CDDP shows promising activity with acceptable toxicities against colorectal cancer.

Conclusions

A combination of S-1 and CDDP could be a standard therapy for treating colorectal carcinoma.

Keywords

Colorectal cancer 5-FU S-1 Cisplatin Chemotherapy 

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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Kazumi Uchida
    • 1
    Email author
  • Kazuhiko Hayashi
    • 1
  • Hidekazu Kuramochi
    • 1
  • Go Nakajima
    • 1
  • Yuji Inoue
    • 1
  • Masakazu Yamamoto
    • 1
  1. 1.Institute of GastroenterologyTokyo Women’s Medical UniversityTokyoJapan

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