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Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias

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References

  • Al-Tassan N, Chmiel NH, Maynard J, Fleming N, Livingston AL, Williams GT, Hodges AK, Davies DR, David SS, Sampson JR, Cheadle JP (2002) Inherited variants of MYH associated with somatic G:C→T:A mutations in colorectal tumors. Nat Genet 30:227–232

    Article  CAS  PubMed  Google Scholar 

  • Cheson BD, Cassileth PA, Head DR, Schiffer CA, Bennett JM, Bloomfield CD, Brunning R, Gale RP, Grever MR, Keating MJ, Sawitsky A, Stass S, Weinstein H, Woods GW (1990) Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia. J Clin Oncol 8:813–819

    CAS  PubMed  Google Scholar 

  • Guan Y, Manuel RC, Arvai AS, Parikh SS, Mol CD, Miller JH, Lloyd S, Tainer JA (1998) MutY catalytic core, mutant and bound adenine structures define specificity for DNA repair enzyme superfamily. Nat Struct Biol 5:1058–1064

    Article  CAS  PubMed  Google Scholar 

  • Horwitz M (1997) The genetics of familial leukemia. Leukemia 11:1347–1359

    Article  CAS  PubMed  Google Scholar 

  • Jones S, Emmerson P, Maynard J, Best JM, Jordan S, Williams GT, Sampson JR, Cheadle JP (2002) Biallelic germline mutations in MYH predispose to multiple colorectal adenoma and somatic G:C→T:A mutations. Hum Mol Genet 11:2961–2967

    Article  CAS  PubMed  Google Scholar 

  • Peltomaki P (2001) Deficient DNA mismatch repair: a common etiologic factor for colon cancer. Hum Mol Genet 10:735–740

    CAS  PubMed  Google Scholar 

  • Ricciardone MD, Özçelik T, Cevher B, Özdağ H, Tuncer M, Gürgey A, Uzunalimoğlu Ö, Çetinkaya H, Tanyeli A, Erken E, Öztürk M (1999) Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type 1. Cancer Res 59:290–293

    CAS  PubMed  Google Scholar 

  • Whiteside D, McLeod R, Graham G, Steckley JL, Booth K, Somerville MJ, Andrew SE (2002) A homozygous germ-line mutation in the human MSH2 gene predisposes to hematological malignancy and multiple café-au-lait spots. Cancer Res 62:359–362

    CAS  PubMed  Google Scholar 

  • Wang Q, Lasset C, Desseigne F, Frappaz D, Bergeron C, Navarro C, Ruano E, Puisieux A (1999) Neurofibromatosis and early onset of cancers in hMLH1-deficient children. Cancer Res 59:294–297

    CAS  PubMed  Google Scholar 

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Acknowledgements

This work was supported by SBAG-2513 from the Turkish Scientific and Technical Research Council (TÜBİTAK) and Bilkent University Research Fund.

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Correspondence to Tayfun Özçelik.

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Akyerli, C.B., Özbek, U., Aydın-Sayitoğlu, M. et al. Analysis of MYH Tyr165Cys and Gly382Asp variants in childhood leukemias. J Cancer Res Clin Oncol 129, 604–605 (2003). https://doi.org/10.1007/s00432-003-0483-1

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  • DOI: https://doi.org/10.1007/s00432-003-0483-1

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