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Clinicopathological significance of pRb2/p130 expression in squamous cell carcinoma of the esophagus

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Abstract

Purpose.

The aim of the current study was to find out the significance of the immunohistochemical expression of pRb2/p130, which is a member of the retinoblastoma gene family, in squamous cell carcinoma of the esophagus.

Methods.

We analyzed immunohistochemically the expression of pRb2/p130 of 107 squamous cell carcinomas (SCCs) of the esophagus and the correlation of pRb2/p130 expression with clinicopathological features was investigated.

Results.

Expression of pRb2/p130 was observed in 42 SCCs (39.3%). There was a significant correlation of pRb2/p130 expression with the histological type of well-differentiated SCC ( P < 0.0001). The survival rate of patients with esophageal SCCs expressing pRb2/p130 was significantly better than that of patients with tumors without pRb2/p130 expression ( P = 0.016). A multivariate analysis demonstrated that pRb2/p130 expression ( P = 0.026), venous invasion ( P = 0.028), and TNM stage ( P = 0.044) were independent prognostic indicators in patients with esophageal SCCs.

Conclusions.

Differentiation of esophageal SCC might be partially mediated by the pRb2/p130 gene, and pRb2/p130 expression can additionally be an indicator of the better prognosis of patients with esophageal SCCs.

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Authors and Affiliations

  1. Department of General Surgery, Fukuoka Dental College Hospital, 2–15–1, Tamura, Sawara Ward, Fukuoka, 814–0193, Japan

    Tadahiro Nozoe & Daisuke Korenaga

  2. Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan

    Shuhei Itoh, Motonori Futatsugi & Yoshihiko Maehara

Authors
  1. Tadahiro Nozoe
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  2. Daisuke Korenaga
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  3. Shuhei Itoh
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  4. Motonori Futatsugi
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  5. Yoshihiko Maehara
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Corresponding author

Correspondence to Tadahiro Nozoe.

Additional information

This study is supported by a grant-in-aid from the Ministry of Education, Science, Sports, and Culture of Japan (Frontier Research Grant and Grant for Science Research 13671308)

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Nozoe, T., Korenaga, D., Itoh, S. et al. Clinicopathological significance of pRb2/p130 expression in squamous cell carcinoma of the esophagus. J Cancer Res Clin Oncol 128, 691–696 (2002). https://doi.org/10.1007/s00432-002-0395-5

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  • DOI: https://doi.org/10.1007/s00432-002-0395-5

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