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Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation – successful treatment with high-dose methylprednisolone and defibrotide

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Abstract.

Veno-occlusive disease (VOD) is a life-threatening complication following allogeneic or autologous stem cell transplantation. We report on a patient with a high grade B-cell lymphoma who presented 28 days after the second autologous stem cell transplantation with weight gain, ascites, hyperbilirubinemia, and liver venules occlusion as demonstrated by sonography. Starting with high-dose methylprednisolone treatment followed by defibrotide maintenance therapy the patient showed dramatic complete response of VOD, resulting in a normal sonography of the liver and normalization of laboratory values. The response of the occlusion of nearly all liver venules underlines the value of anti-inflammatory treatment combined with new thrombolytic medication such as defibrotide for the treatment of severe VOD.

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Authors and Affiliations

  1. Klinik und Poliklinik für Innere Medizin II (Hämatologie, Onkologie, Endokrinologie und Stoffwechselerkrankungen) der Friedrich-Schiller-Universität Jena, Erlanger Allee 101, 07740 Jena, Germany, , , , ,

    H. Sayer,  U. Will,  K. Schilling,  T. Vogt,  K. Wollina &  K. Höffken

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  1. H. Sayer
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  2. U. Will
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  3. K. Schilling
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  4. T. Vogt
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  5. K. Wollina
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  6. K. Höffken
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Sayer, .H., Will, .U., Schilling, .K. et al. Hepatic veno-occlusive disease (VOD) with complete occlusion of liver venules after tandem autologous stem cell transplantation – successful treatment with high-dose methylprednisolone and defibrotide. J Cancer Res Clin Oncol 128, 148–152 (2002). https://doi.org/10.1007/s00432-001-0316-z

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  • DOI: https://doi.org/10.1007/s00432-001-0316-z

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