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Anti-thymocyte globulin, cyclosporin A and granulocyte colony-stimulating factor for severe aplastic anaemia complicating paediatric liver transplantation

  • HEMATOLOGY / ONCOLOGY
  • Published:
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Abstract

We describe a sustained trilineage haematopoietic response to intensified immunosuppressive therapy with anti-thymocyte globulin, cyclosporin A and recombinant human granulocyte colony-stimulating factor in a 4-year-old girl, who developed severe aplastic anaemia after orthotopic liver transplantation for fulminant liver failure induced by non A-E hepatitis. The outcome was successful and allows the following.

Conclusion Intense immunosuppression in combination with haemopoetic growth factors and antimicrobial prophylaxis should be considered as first line therapy in severe aplastic anaemia after orthotopic liver trans plantation.

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Authors and Affiliations

  1. Department of Child Health, King's College Hospital, Denmark Hill, London SE5 9RS, UK, Tel.: 44-171-3463214, Fax: 44-171-3463564, , , , , , DK

    N. Hadzic, A. J. Baker & G. Mieli-Vergani

  2. Department of Haematological Medicine, King's College Hospital, London, UK, , , , , , GB

    M. Layton

  3. Liver Transplant Surgical Service, King's College Hospital, London, UK, , , , , , GB

    N. D. Heaton & M. Rela

Authors
  1. N. Hadzic
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  2. M. Layton
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  3. N. D. Heaton
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  4. M. Rela
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  5. A. J. Baker
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  6. G. Mieli-Vergani
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Additional information

Received: 19 April 1997 / Accepted: 31 May 1997

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Hadzic, N., Layton, M., Heaton, N. et al. Anti-thymocyte globulin, cyclosporin A and granulocyte colony-stimulating factor for severe aplastic anaemia complicating paediatric liver transplantation. Eur J Pediatr 157, 107–108 (1998). https://doi.org/10.1007/s004310050779

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  • DOI: https://doi.org/10.1007/s004310050779

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