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European Journal of Pediatrics

, Volume 156, Issue 7, pp 550–552 | Cite as

Invasive antenatal procedures and requirement for neonatal intensive care unit admission

  • A. Greenough
  • B. Yuksel
  • S. Naik
  • P. Cheeseman
  • K. H. Nicolaides
NEONATOLOGY

Abstract

Neonatal respiratory difficulties are increased following second trimester amniocentesis. In preterm, prolonged rupture of the membranes, respiratory outcome is particularly poor when rupture occurs in the first trimester. It therefore seems likely that first trimester/early amniocentesis (EA) would be associated with severe respiratory problems necessitating a high neonatal intensive care unit (NICU) admission rate. To test that hypothesis, the requirement for admission to the NICU of 278 infants whose mothers had undergone EA, 262 whose mothers had undergone chorion villus sampling (CVS group) and 264 controls whose mothers had undergone no invasive procedures were reviewed as were their diagnoses if they needed admission. There was no significant difference in the mode of delivery, gestational age or gender distribution of the three groups and the median maternal age of the EA and CVS groups was similar. Nineteen EA, eight CVS and five control infants required admission to the NICU (EA versus controls, P < 0.01; EA versus CVS plus controls, P < 0.005). Nine EA, one CVS and four control infants had suffered respiratory problems (EA versus CVS P < 0.05). Logistic regression analysis demonstrated that immaturity and EA were significantly associated with a requirement for NICU admission. We conclude infants whose mothers have undergone EA may be at increased risk for NICU admission, this is partly due to respiratory problems but the association is uncommon.

Key words Amniocentesis chorion villus sampling Neonatal intensive care 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Greenough
    • 1
  • B. Yuksel
    • 1
  • S. Naik
    • 1
  • P. Cheeseman
    • 1
  • K. H. Nicolaides
    • 2
  1. 1.Department of Child Health, King's College Hospital, London SE5 9RS, U.K. Fax +44 171 924 9365GB
  2. 2.The Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, U.K.GB

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