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European Journal of Pediatrics

, Volume 156, Issue 7, pp 546–549 | Cite as

Hepatitis C and G Virus infections in polytransfused children

  • J.-L. Chung
  • J.-H. Kao
  • M.-S. Kong
  • C.-P. Yang
  • I.-J. Hung
  • T.-Y. Lin
  • J. H. Kao
INFECTIOUS DISEASES

Abstract

The prevalence of hepatitis C virus (HCV) and a newly identified hepatitis G virus (HGV) and their clinical significance were studied in 42 polytransfused Taiwanese children. Serological assays for antibodies against HCV (anti-HCV) and polymerase chain reaction for serum HCV ribonucleic acid (RNA) and HGV RNA were performed. The prevalence of anti-HCV and HGV RNA was 17% and 14%, respectively in 42 polytransfused children. Anti-HCV seropositives had a significantly higher mean age, peak serum transaminase level, and longer transfusion duration than seronegatives, while children with HGV infection usually had no or only mild hepatitis activities. The prevalence of anti-HCV dropped sharply after implementation of anti-HCV screening, however the prevalence of HGV viraemia remained unchanged.

Conclusion HGV infection is not uncommon in polytransfused Taiwanese children and the virus does not cause significant hepatitis compared to HCV infection. Current blood donor screening for anti-HCV can effectively protect polytransfused children from HCV infection but the impact of additional screening for HGV markers awaits further studies.

Key words Hepatitis C virus Hepatitis G virus Thalassaemic children 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J.-L. Chung
    • 1
  • J.-H. Kao
    • 2
  • M.-S. Kong
    • 3
  • C.-P. Yang
    • 3
  • I.-J. Hung
    • 3
  • T.-Y. Lin
    • 3
  • J. H. Kao
    • 4
  1. 1.Department of Paediatrics, Hsin-Tai Hospital, Taipei, Taiwan, R.O.C.TW
  2. 2.Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, R.O.C.TW
  3. 3.Department of Paediatrics, Chang Gung Children's Hospital, Taipei, Taiwan, R.O.C.TW
  4. 4.Hepatitis Research Centre, National Taiwan University Hospital, 1 Chang-Te St., Taipei, Taiwan 100 Tel.: 886-02-3970800 ext 7302; Fax: 886-2-3317624TW

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