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European Journal of Pediatrics

, Volume 156, Issue 7, pp 533–536 | Cite as

Continuous plasma resin perfusion for detoxification of methotrexate

  • J. Greil
  • P. A. Wyss
  • K. Ludwig
  • S. Bonakdar
  • J. Scharf
  • J. D. Beck
  • H. Ruder
HEMATOLOGY/ONCOLOGY

Abstract

Acute renal failure is a rare but very severe side-effect of methotrexate (MTX) treatment requiring extracorporeal detoxification. A new detoxification regime, consisting of a haemodiafiltration (HDF) and continuous plasma resin perfusion (PRP) over anion exchange resin column with high affinity for MTX, was used for treatment of MTX-induced acute renal failure in a 2-year-old boy with medulloblastoma. More than 99% of MTX was removed from plasma by perfusion over the resin column resulting in a marked decrease of MTX plasma half-life. No haematological complications occurred.

Conclusion The use of PRP alone or in combination with HDF is a new and effective treatment strategy for extracorporeal detoxification of MTX.

Key words Methotrexate Acute renal failure Haemodiafiltration Plasma adsorption Ion-exchange resins 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J. Greil
    • 1
  • P. A. Wyss
    • 2
  • K. Ludwig
    • 1
  • S. Bonakdar
    • 1
  • J. Scharf
    • 1
  • J. D. Beck
    • 1
  • H. Ruder
    • 1
  1. 1.Klinik mit Poliklinik für Kinder und Jugendliche, University of Erlangen-Nürnberg, Loschgestrasse 15, D-91054 Erlangen, GermanyDE
  2. 2.Swiss Toxicological Information Centre, Klosbachstrasse 107, CH-8030 Zürich, Switzerland Tel.: +49-9131-853108 (853118); Fax: +49-9131-856097CH

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