Abstract
Acute renal failure is a rare but very severe side-effect of methotrexate (MTX) treatment requiring extracorporeal detoxification. A new detoxification regime, consisting of a haemodiafiltration (HDF) and continuous plasma resin perfusion (PRP) over anion exchange resin column with high affinity for MTX, was used for treatment of MTX-induced acute renal failure in a 2-year-old boy with medulloblastoma. More than 99% of MTX was removed from plasma by perfusion over the resin column resulting in a marked decrease of MTX plasma half-life. No haematological complications occurred.
Conclusion The use of PRP alone or in combination with HDF is a new and effective treatment strategy for extracorporeal detoxification of MTX.
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Received: 27 June 1996 / Accepted: 17 December 1996
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Greil, J., Wyss, P., Ludwig, K. et al. Continuous plasma resin perfusion for detoxification of methotrexate. Eur J Pediatr 156, 533–536 (1997). https://doi.org/10.1007/s004310050656
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DOI: https://doi.org/10.1007/s004310050656