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Platelet indices in overweight and obese children

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Abstract

The aim of the study was to determine the association between platelet indices and obesity in children. A total of 190 overweight or obese children (mean age: 13.29 ± 2.54, M/F: 0.74) and 100 normal-weight children (mean age: 12.72 ± 2.23, M/F:1.04) were enrolled in the study. Platelet count (PLT), platelet indices, and ratios were determined. No significant difference was observed in terms of mean platelet volume (MPV) and platelet distribution width (PDW) levels and MPV/plateletcrit (PCT) and PDW/PCT ratios between overweight, obese, and normal-weight groups, whereas significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT ratios between each group. PLT and PCT levels were significantly higher in the obese group than in the overweight and normal-weight groups (P = 0.003, P = 0.002, respectively). Children with obesity had lower MPV/PLT and PDW/PLT ratios than the other groups (P = 0.001, P = 0.02, respectively). Overweight and obese children with insulin resistance (IR) had higher PLT and lower MPV/PLT, and PDW/PLT ratios than the children without IR (P = 0.034, P = 0.04, P = 0.013, respectively).

Conclusion: Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children.

What is Known:

• Obesity is associated with a chronic low-grade systemic inflammation.

• Platelets play a crucial role in coagulation, hemostasis, thrombosis, immunomodulatory processes, inflammation, and atherothrombosis.

What is New:

• Significant differences were observed in terms of PLT, PCT, MPV/PLT, and PDW/PLT between overweight, obese, and normal-weight children.

• Overweight and obese children with insulin resistance had higher PLT and lower MPV/PLT and PDW/PLT ratios than the children without insülin resistance.

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Data availability

N/A.

Abbreviations

ALT:

Alanine aminotransferase

AST:

Aspartate aminotransferase

BMI:

Body mass index

Hb:

Hemoglobin

HbA1c:

Glycated hemoglobin

HDL:

High-density lipoprotein

HOMA-IR:

Homeostasis model assessment insulin resistance

IR:

Insulin resistance

LDL:

Low-density lipoprotein

MPV:

Mean platelet volume

PCT:

Plateletcrit

PDW:

Platelet distribution width

PLT:

Platelet

TG:

Triglyceride

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Authors and Affiliations

  1. Istinye State Hospital, Istinye Street No. 98, Sariyer, Istanbul, Turkey

    Derya Kalyoncu

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Conceptualization, methodology, formal analysis and investigation, writing—original draft preparation, and writing—review and editing: Derya Kalyoncu.

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Correspondence to Derya Kalyoncu.

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Kalyoncu, D. Platelet indices in overweight and obese children. Eur J Pediatr 182, 3989–3995 (2023). https://doi.org/10.1007/s00431-023-05082-1

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