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Table 2 Main published institutional protocols about the management of pediatric stroke in the last 5 years 49, 50, 52, 53, 54, 55

From: Acute ischemic stroke in childhood: a comprehensive review

Article No. of enrolled patients Number of patients diagnosticated arterial ischemic stroke Time of application of protocol Main symptoms at onset PedNHISS Time to neuroimaging Number of treated patients % of success of treatment Number of patients with complications
Rivkin et al. (2019)49 65 pt presenting with brain attack symptoms 6 2.5 years Focal motor symptoms, sensory deficit, headache  < 4 (65% patients); > 4 (32% patients); not documented in 3 patients 82 min Not available Not available Not available
Tabone et al. (2017)50 13 patients with acute ischemic stroke 13 3.3 years Focal motor symptoms, language disorder Median pedNIHSS 10 165 min 15 (11 pt rTPA, 4 pt endovascular procedure) Not available No intracranial or peripheral bleeding after treatment. One early death (malignant stroke). mRS score at 3 months 0–2
Ladner et al. (2015)55 124 stroke alerts 21 3 years Focal motor symptoms, altered mental status, headache Not available 94 min (to MRI) 59 min (to CT) 11 (1 pt rTPA, 2 pt mechanical thrombectomy) Not available Median pediatric stroke outcome measure 0.75 (IQR, 0–2.13), mild-to-moderate ongoing neurological deficits with effect on function
DeLaroche et al. (2016)52 36 stroke alert activations 7 4 years Neurological deficit, headache, altered mental status, gait abnormalities, seizures Not available 46 min (to CT) 320 min (to MRI) Not available 100% None patient reported complications (64% of pts are discharged home. 36% to in-patients rehabilitation. No deaths)
Shack et al. (2016)53 112 122 7 years Not available Median pedNIHSS 7 (4–12) 90 min Not available Not available Not available
Wharton et al. (2020)54 385 stroke alert activation 80 stroke (not specified acute ischemic/haemorrhagic) 7 years Not available Median pedNIHSS 7.5–10 79 min 57 (0 pt rTPA, 4 pt endovascular procedure) Not available Not available