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Response to single oral dose vitamin D in obese vs non-obese vitamin D–deficient children

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Abstract

Obese individuals are prone to vitamin D deficiency because of sequestration of vitamin D in their body fat. We planned to evaluate the rise in serum 25(OH)D levels in vitamin D–deficient obese vs normal body mass index(BMI) children, after administration of identical single dose of vitamin D. Twenty-two obese and 22 normal BMI children with serum 25 (OH)D < 20 ng/mL were given single oral dose 150,000 IU vitamin D, and 25 (OH)D levels were measured at 1 week and 1 month post-intervention. Results show that rise in 25(OH)D level from baseline was about 2.2 times lesser in obese compared with children with normal BMI, both at 1 week and at 1 month. The rise in 25(OH)D from baseline to 1 month was inversely correlated to BMI (r = − 0.56, p = < 0.001), waist circumference (r = − 0.48, p = 0.001), total fat mass (r = − 0.58, p < 0.001), and fat mass index (r = − 0.59, p < 0.001).

Conclusion: The obese children have a 2.2 times lower rise in serum vitamin D levels as compared with the normal BMI children for the same dose of vitamin D supplementation.

What is Known:

• The obese individuals are prone to vitamin D deficiency and may be given higher doses of vitamin D supplementation.

What is New:

• Our study demonstrates that obese children have 2.2 times lesser rise in serum 25(OH)D concentrations as compared with normal BMI children when administered similar oral dose vitamin D.

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Abbreviations

ALP:

Alkaline phosphatase

BMI:

Body mass index

nBMI:

Normal BMI

Ca:

Calcium

DXA:

Dual-energy X-ray absorptiometry

FMI:

Fat mass index

iPTH:

Intact parathormone

P:

Phosphate

25(OH)D:

Serum 25(OH)D

SD:

Standard deviation

SPSS:

Statistical Package for Social Science

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Delhi, 110031, India

    Akshay Tayde, Medha Mittal & Anuradha Rai

  2. Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India

    Rajesh Khadgawat

  3. Department of Biochemistry, Chacha Nehru Bal Chikitsalaya, Delhi, India

    Shikha Sharma

  4. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

    V Sreenivas

Authors
  1. Akshay Tayde
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  2. Medha Mittal
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  4. Shikha Sharma
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  5. V Sreenivas
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  6. Anuradha Rai
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Contributions

AT: Data collection and analysis, drafting of the manuscript, approval of final manuscript. MM: conceptualization and design of study, data collection and analysis, drafting of manuscript and approval of final manuscript. RK: conceptualization and design of study, data analysis and interpretation, editing of manuscript and approval of final manuscript. SS: data collection and anlaysis, approval of final manuscript. SV: conceptualization and design of study, data analysis and interpretation, approval of final manuscript. AR: data collection, approval of final manuscript. 

Corresponding author

Correspondence to Medha Mittal.

Ethics declarations

The study was performed in line with ethical standards of Helsinki Declaration.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Ethical Approval was obtained from Institutional Ethics Committee, Chacha Nehru Bal Chikitsalaya, Delhi.

Additional information

Communicated by Peter de Winter

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Tayde, A., Mittal, M., Khadgawat, R. et al. Response to single oral dose vitamin D in obese vs non-obese vitamin D–deficient children. Eur J Pediatr 180, 1043–1050 (2021). https://doi.org/10.1007/s00431-020-03831-0

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  • DOI: https://doi.org/10.1007/s00431-020-03831-0

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