Abstract
Bronchopulmonary dysplasia (BPD) is one of the most important sequelae of premature birth. There is concern that in some patients, lung injuries early in life may have lifelong consequences. In this retrospective observational cohort study, lung function evolution in children with BPD was investigated from childhood to young adulthood. Data from 355 pulmonary function tests (PFT) in 24 patients were analyzed, with a median age at first PFT of 7.6 years and at last PFT 18.2 years. FEV1 and FEV1/FVC were below the 5th percentile in respectively 18 and 13/24 patients. Comparing first and last measurement, there was significant worsening in FEV1 from a mean of 71.3% pred (SD 18.3) to 66.7% pred (SD 21.7) (p < 0.05) and in FEV1/FVC from 85.4% pred (SD 15.2) to 79.8% pred (SD 17.3) (p = 0.01). Evaluation of the individual lung function changes with linear regression showed deterioration in FEV1, FVC, and FEV1/FVC in respectively 17, 13, and 17/24 patients. Total group analysis showed significant deterioration in FEV1 (− 0.7%/year, p = 0.002) and FEV1/FVC (− 0.5%/year, p = 0.01). None of the 11 patients born up to 1990 improved in FEV1 vs 7 of the 13 patients born after 1990 (p = 0.006).
Conclusion: This points out to further deterioration of the lung function during childhood in this selected group of children with BPD.
What is Known: • Data on longitudinal changes in lung function in children with BPD are scarce. | |
What is New: • In children with BPD at the severe end of the disease spectrum, lung function does not improve over time. On the contrary, in two-thirds of the subjects studied FEV1and FEV1/FVC worsen over time. • Lung function evolution towards adulthood was somewhat more favorable in children born after 1990 compared with those born earlier, probably reflecting improvements in neonatal care in subjects with new type BPD. |
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Abbreviations
- BD:
-
Bronchodilator
- BPD:
-
Bronchopulmonary dysplasia
- FEV1 :
-
Forced expiratory volume in 1 s
- FVC:
-
Forced vital capacity
- LLN:
-
Lower limit of normal
- PFT:
-
Pulmonary function test
- pp:
-
Percent of predicted
References
Baraldi E, Carraro S, Filippone M (2009) Bronchopulmonary dysplasia: definitions and long-term respiratory outcome. Early Hum Dev 85:S1–S3
Ehrenkranz RA, Walsh MC, Vohr BR, Jobe AH, Wright LL, Fanaroff AA, Wrage LA, Poole K (2005) Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics 116:1353–1360
Jobe AH, Bancalari E (2001) Bronchopulmonary dysplasia. Am J Respir Crit Care Med 163:1723–1729
Baraldi E, Filippone M (2007) Chronic lung disease after premature birth. N Engl J Med 357:1946–1955
Narang I, Baraldi E, Silverman M, Bush A (2006) Airway function measurements and the long-term follow-up of survivors of preterm birth with and without chronic lung disease. Pediatr Pulmonol 41:497–508
Narayanan M, Owers-Bradley J, Beardsmore CS, Mada M, Ball I, Garipov R, Panesar KS, Kuehni CE, Spycher BD, Williams SE, Silverman M (2012) Alveolarization continues during childhood and adolescence: new evidence from helium-3 magnetic resonance. Am J Respir Crit Care Med 185:186–191
Butler JP, Loring SH, Patz S, Tsuda A, Yablonskiy DA, Mentzer SJ (2012) Evidence for adult lung growth in humans. N Engl J Med 367:244–247
Narayanan M, Beardsmore CS, Owers-Bradley J, Dogaru CM, Mada M, Ball I, Garipov RR, Kuehni CE, Spycher BD, Silverman M (2013) Catch-up alveolarization in ex-preterm children: evidence from (3)He magnetic resonance. Am J Respir Crit Care Med 187:1104–1109
Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH, Enright PL, Hankinson JL, Ip MS, Zheng J et al (2012) Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations. Eur Respir J 40:1324–1343
Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC (1993) Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, European Community for steel and coal. Official statement of the European Respiratory Society. Eur Respir J Suppl 16:5–40
Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, van der Grinten CP, Gustafsson P, Jensen R, Johnson DC, MacIntyre N, McKay R, Navajas D, Pedersen OF, Pellegrino R, Viegi G, Wanger J, ATS/ERS Task Force (2005) Standardisation of spirometry. Eur Respir J 26:319–338
Dyer C (2012) The interaction of ageing and lung disease. Chron Respir Dis 9:63–67
Northway WH Jr, Moss RB, Carlisle KB, Parker BR, Popp RL, Pitlick PT, Eichler I, Lamm RL, Brown BW Jr (1990) Late pulmonary sequelae of bronchopulmonary dysplasia. N Engl J Med 323:1793–1799
Filippone M, Baraldi E (2011) On early life risk factors for COPD. Am J Respir Crit Care Med 183:415–416 author reply 416
Smyth JA, Tabachnik E, Duncan WJ, Reilly BJ, Levison H (1981) Pulmonary function and bronchial hyperreactivity in long-term survivors of bronchopulmonary dysplasia. Pediatrics 68:336–340
Filippone M, Sartor M, Zacchello F, Baraldi E (2003) Flow limitation in infants with bronchopulmonary dysplasia and respiratory function at school age. Lancet 361:753–754
Blayney M, Kerem E, Whyte H, O'Brodovich H (1991) Bronchopulmonary dysplasia: improvement in lung function between 7 and 10 years of age. J Pediatr 118:201–206
Koumbourlis AC, Motoyama EK, Mutich RL, Mallory GB, Walczak SA, Fertal K (1996) Longitudinal follow-up of lung function from childhood to adolescence in prematurely born patients with neonatal chronic lung disease. Pediatr Pulmonol 21:28–34
Doyle LW, Faber B, Callanan C, Freezer N, Ford GW, Davis NM (2006) Bronchopulmonary dysplasia in very low birth weight subjects and lung function in late adolescence. Pediatrics 118:108–113
Vollsaeter M, Roksund OD, Eide GE, Markestad T, Halvorsen T (2013) Lung function after preterm birth: development from mid-childhood to adulthood. Thorax 68:767–776
Hirata K, Nishihara M, Kimura T, Shiraishi J, Hirano S, Kitajima H, Fujimura M (2017) Longitudinal impairment of lung function in school-age children with extremely low birth weights. Pediatr Pulmonol 52:779–786
Jobe AH (2013) Good news for lung repair in preterm infants. Am J Respir Crit Care Med 187:1043–1044
Merkus PJ, van Pelt W, van Houwelingen JC, van Essen-Zandvliet LE, Duiverman EJ, Kerrebijn KF, Quanjer PH (2004) Inhaled corticosteroids and growth of airway function in asthmatic children. Eur Respir J 23(6):861–868
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Thanks to Mrs. Els Aertgeerts for secretarial assistance.
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FC, FV, MP, MM, and KDB designed the study. FC and FV collected the data and performed the analyses. FC wrote the draft manuscript. FC, FV, MP, MM, and KDB reviewed the manuscript and made significant additions. All authors take responsibility for the data and results.
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The Ethics Committee of UZ Leuven approved the study.
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Cardoen, F., Vermeulen, F., Proesmans, M. et al. Lung function evolution in children with old and new type bronchopulmonary dysplasia: a retrospective cohort analysis. Eur J Pediatr 178, 1859–1866 (2019). https://doi.org/10.1007/s00431-019-03453-1
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DOI: https://doi.org/10.1007/s00431-019-03453-1