Advertisement

European Journal of Pediatrics

, Volume 177, Issue 6, pp 955–960 | Cite as

Eyelash length for the diagnosis of atopic dermatitis and ichthyosis vulgaris in children—a case control study

  • Mehak Singh
  • Manoj Pawar
Original Article

Abstract

Eyelash trichomegaly (ET) is increased length (≥ 12 mm), curling, pigmentation, or thickness of eyelashes. Among acquired causes, allergic diseases and atopic dermatitis (AD) have been found to be associated with eyelash trichomegaly especially in children; however, to date, this claim has not been studied in detail. To compare the eyelash lengths of AD and ichthyosis vulgaris (IV) patients with those of age- and sex-matched patients with unrelated skin disorders, we measured (with a digital Vernier caliper) and compared the eyelash lengths of AD (n = 58) and IV (n = 31) patients to those of age- and sex-matched patients with unrelated skin disorders (n = 178). The eyelashes of the AD and male IV patients were found to be significantly longer than those of the controls (p < 0.05). The severity of atopic dermatitis, i.e., SCORAD of > 50, hyperlinearity of palms and soles, and high IgE levels significantly correlated with the long eyelashes. The limitations of study are single-center study and filaggrin gene mutation in patients of IV could not be studied.

Conclusion: Thus, long eyelashes may act as surrogate marker of severe AD and serve as a cutaneous marker of IV patients.

What is Known:

Among acquired causes, allergic diseases and atopic dermatitis have been found to be associated with eyelash trichomegaly especially in children.

What is New:

The severity of atopic dermatitis, i.e., SCORAD of > 50, hyperlinearity of palms and soles, and high IgE levels significantly correlate with the long eyelashes; thus, long eyelashes may act as surrogate marker of severe atopic dermatitis.

It may also serve as a cutaneous marker of ichthyosis vulgaris especially in male patients and patients with palmoplantar hyperlinearity.

Keywords

Trichomegaly Eyelashes Atopic dermatitis Ichthyosis vulgaris 

Abbreviations

AD

Atopic dermatitis

DASI

Dry skin/ichthyosis area and severity index

ET

Eyelash trichomegaly

IV

Ichthyosis vulgaris

SCORAD

Scoring Atopic Dermatitis

Notes

Authors’ contributions

MS designed and supervised the project, supervised data collection and analysis, and first drafted the manuscript. MP assisted in data management, was responsible for sample management, and revised the manuscript for important intellectual content. All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work.

Compliance with ethical standards

The study was approved by the local Ethics Committee of Nashik, India.

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all patients/parents (in the case of minor patients).

References

  1. 1.
    Gray H (1944) Trichomegaly or movie lashes. Stanford Med Bull 2:157–158Google Scholar
  2. 2.
    Harrison DA, Mallaney PB (1997) Familial trichomegaly. Arch Ophthalmol 115:1602–1603CrossRefPubMedGoogle Scholar
  3. 3.
    Levin AV, Seidman DJ, Nelson LB, Jackson LG (1990) Ophthalmologic findings in the Cornelia de Lange syndrome. Pediatr Ophthalmol Strabismus 27:94–102Google Scholar
  4. 4.
    Haritoglou C, Rudolph G, Kalpadakis P, Boergen KP (2003) Congenital trichomegaly (Oliver-McFarlane syndrome): a case report with 9 years’ follow-up. Br J Ophthalmol 87:119–120CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Toro J, Turner M, Gahl WA (1999) Dermatologic manifestations of Hermansky-Pudlak syndrome in patients with and without a 16-base pair duplication in the HPSI gene. Arch Dermatol 135:774–780PubMedGoogle Scholar
  6. 6.
    Santiago M, Travassos AC, Rocha MC, Souza S (2000) Hypertrichosis in systemic lupus erythematosus (SLE). Clin Rheumatol 19:245–246CrossRefPubMedGoogle Scholar
  7. 7.
    Sharma RC, Mahajan VK, Sharma NL, Sharma A (2002) Trichomegaly of the eyelashes in dermatomyositis. Dermatology 205:305CrossRefPubMedGoogle Scholar
  8. 8.
    Kaplan MH, Sadick NS, Talmor M (1991) Acquired trichomegaly of the eyelashes: a cutaneous marker of acquired immunodeficiency syndrome. J Am Acad Dermatol 25:801–804CrossRefPubMedGoogle Scholar
  9. 9.
    Schneiderman PI, Grossman ME (2006) A clinician’s guide to dermatologic differential diagnosis. Boca Raton, Informa HealthcareCrossRefGoogle Scholar
  10. 10.
    Hernandez-Nunez A, Fernandez-Herrera J, Buceta LR, Garcia-Diez A (2002) Trichomegaly following treatment with interferon alpha-2b. Lancet 359:1107CrossRefPubMedGoogle Scholar
  11. 11.
    Weaver DT, Bartley GB (1990) Cyclosporine-induced trichomegaly. Am J Ophthalmol 109:239CrossRefPubMedGoogle Scholar
  12. 12.
    Woo TL, Francis IC (2001) Intermittent blurred vision and trichomegaly due to latanoprost. Clin Exp Ophthalmol 29:272–273CrossRefPubMedGoogle Scholar
  13. 13.
    Medina Mendez CA, Ma PC, Singh AD (2014) Acquired trichomegaly: trichomegaly secondary to erlotinib. JAMA Ophthalmol 132(9):1051CrossRefPubMedGoogle Scholar
  14. 14.
    Marks MB (1977) Recognizing the allergic person. Am Fam Physician 16:72–79PubMedGoogle Scholar
  15. 15.
    Levy Y, Segal N, Ben-Amitai D, Danon YL (2004) Eyelash length in children and adolescents with allergic diseases. Pediatr Dermatol 21(5):534–537CrossRefPubMedGoogle Scholar
  16. 16.
    Möhrenschlager M, Weidinger S, Huss-Marp J, Krämer U, Behrendt H, Ring J (2005) Do gender-specific differences in eyelash length in 5- to 6-year-old preschool children with and without atopic eczema exist? Results from the Miriam study conducted in Augsburg, Germany. Pediatr Dermatol 22(6):576–577CrossRefPubMedGoogle Scholar
  17. 17.
    Silverberg NB (2017) Typical and atypical clinical appearance of atopic dermatitis. Clin Dermatol 35(4):354–359CrossRefPubMedGoogle Scholar
  18. 18.
    Oji V, Traupe H (2009) Ichthyosis: clinical manifestations and practical treatment options. Am J Clin Dermatol 10(6):351–364CrossRefPubMedGoogle Scholar
  19. 19.
    Bremmer SF, Hanifin JM, Simpson EL (2008 Jul) Clinical detection of ichthyosis vulgaris in an atopic dermatitis clinic: implications for allergic respiratory disease and prognosis. J Am Acad Dermatol 59(1):72–78CrossRefPubMedGoogle Scholar
  20. 20.
    Williams HC, Burney PGJ, Pembroke AC, Hay RJ (1996) On behalf of the UK diagnostic criteria for atopic dermatitis working party. Validation of the UK diagnostic criteria for atopic dermatitis in a population setting. Br J Dermatol 135(1):12–17CrossRefPubMedGoogle Scholar
  21. 21.
    Rullo VEV, Segato A, Kirsh A, Sole D (2008) Severity scoring of atopic dermatitis: a comparison of two scoring systems. Allergol Immunopathol (Madr) 36(4):205–211CrossRefGoogle Scholar
  22. 22.
    Serup J (1995 Aug) EEMCO guidance for the assessment of dry skin (xerosis) and ichthyosis: clinical scoring systems. Skin Res Technol 1(3):109–114CrossRefPubMedGoogle Scholar
  23. 23.
    Paul LJ, Cohen PR, Kurzrock R (2012 Jun) Eyelash trichomegaly: review of congenital, acquired, and drug-associated etiologies for elongation of the eyelashes. Int J Dermatol 51(6):631–646CrossRefPubMedGoogle Scholar
  24. 24.
    Olsen EA (1994) Hypertrichosis. In: Olsen EA (ed) Disorders of hair growth. Diagnosis and treatment. McGraw- Hill, New York, pp 315–336Google Scholar
  25. 25.
    Paus R, van der Veen C, Eichmuller S, Kopp T, Hagen E, Müller-Röver S (1998) Generation and cyclic remodeling of the hair follicle immune system in mice. J Invest Dermatol 111:7–18CrossRefPubMedGoogle Scholar
  26. 26.
    Church MK, McGill JI (2002) Human ocular mast cells. Curr Opin Allergy Clin Immunol 2:419–422CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Kaya Skin ClinicNew DelhiIndia
  2. 2.Department of DermatologyMVP’s Dr. VasantraoPawar Medical CollegeNashikIndia

Personalised recommendations