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Relationship between elevated triglyceride levels with the increase of HOMA-IR and HOMA-β in healthy children and adolescents with normal weight

European Journal of Pediatrics volume 174, pages 597–605 (2015)Cite this article

Abstract

To test the hypothesis that mildly elevated triglyceride levels are associated with the increase of homeostasis model assessment of insulin resistance (HOMA-IR) and β-cell function (HOMA-β) indices in healthy children and adolescents with normal weight, we conducted a cross-sectional population study. Based on fasting triglyceride levels, participants were allocated into groups with and without triglyceride levels ≥1.2 mmol/L. Normal weight was defined by body mass index between the 15th and 85th percentiles, for age and gender. Insulin resistance and insulin secretion were estimated using HOMA-IR and HOMA-β indices. A total of 1660 children and adolescents were enrolled, of them 327 (19.7 %) with mildly elevated triglycerides. The multivariate linear regression analysis showed that mildly elevated triglyceride levels in children were associated with HOMA-IR (β = 0.214, p < 0.001), HOMA-β (β = 0.139, p = 0.001), systolic (β = 0.094, p = 0.01), and diastolic blood pressure (β = 0.102, p = 0.007), whereas in adolescents, HOMA-IR (β = 0.267, p < 0.001) and HOMA-β (β = 0.154, p < 0.001), but not systolic (β = 0.029, p = 0.38) and diastolic blood pressure (β = 0.015, p = 0.642), showed association with mildly elevated triglycerides.

Conclusion: Mildly elevated triglyceride levels are associated with increased HOMA-IR and HOMA-β indices in healthy children and adolescents with normal weight.

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Fig. 1

Abbreviations

BMI:

Body mass index

HDL-c:

High-density lipoprotein cholesterol

HOMA-IR:

Homeostasis model assessment of insulin resistance

HOMA-β:

Homeostasis model assessment of β-cell function

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Acknowledgments

This work was supported by grants from the Sistema de Investigación Miguel Hidalgo del Consejo Nacional de Ciencia y Tecnología 2002020201, the Fondo de Apoyo a la Investigación de la Universidad Autónoma de San Luis Potosí CO2-10-13.53, and the Mexican Social Security Institute Foundation, Civil Association.

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Affiliations

  1. Biomedical Research Unit of the Mexican Social Security Institute, Siqueiros 225 esq/Castañeda, 34000, Durango, DGO, Mexico

    Luis E. Simental-Mendía, Argelia Castañeda-Chacón, Martha Rodriguez-Morán & Fernando Guerrero-Romero

  2. Hormone Laboratory, Faculty of Medicine, University of San Luis Potosí, San Luis Potosí, Mexico

    Celia Aradillas-García

Authors
  1. Luis E. Simental-Mendía
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  2. Argelia Castañeda-Chacón
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  3. Martha Rodriguez-Morán
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  4. Celia Aradillas-García
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  5. Fernando Guerrero-Romero
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Corresponding author

Correspondence to Fernando Guerrero-Romero.

Additional information

Revised Dates: 27 August 2014 / 10 September 2014

Communicated by Beat Steinmann

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Simental-Mendía, L.E., Castañeda-Chacón, A., Rodriguez-Morán, M. et al. Relationship between elevated triglyceride levels with the increase of HOMA-IR and HOMA-β in healthy children and adolescents with normal weight. Eur J Pediatr 174, 597–605 (2015). https://doi.org/10.1007/s00431-014-2426-z

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  • DOI: https://doi.org/10.1007/s00431-014-2426-z

Keywords

  • Triglycerides
  • Insulin action
  • Insulin secretion
  • Prepubertal children
  • Puberty