European Journal of Pediatrics

, Volume 173, Issue 2, pp 153–161 | Cite as

Meta-analysis of randomized controlled trials on the efficacy of probiotics in Helicobacter pylori eradication therapy in children

  • Shan Li
  • Xiu-li Huang
  • Jing-zhe Sui
  • Si-yuan Chen
  • Yan-tong Xie
  • Yan Deng
  • Jian Wang
  • Li Xie
  • Tai-jie Li
  • Yu He
  • Qi-liu Peng
  • Xue Qin
  • Zhi-yu Zeng


The efficacy of probiotics supplementation in children undergoing Helicobacter pylori (H. pylori) eradication therapy remains controversial. This study aimed to meta-analyze whether probiotics supplementation in triple therapy could improve H. pylori eradication rates and reduce therapy-related side effects in children. Electronic databases PubMed and Embase were searched to identify all randomized controlled trials in pediatric patients comparing probiotics supplementation with placebo or no extra intervention in H. pylori eradication therapy. Two authors independently extracted the data. Results were expressed as odds ratios (ORs) and accompanying 95 % confidence intervals (CIs). Stata version 12.0 was used to perform all statistical analyses. Seven studies consisting of 508 pediatric patients were included in our study. The pooled ORs (studies n = 7) of eradication rates by intention-to-treat and per-protocol analysis in the probiotics group versus the control group were 1.96 (95 % CI 1.28–3.02) and 2.25 (95 % CI 1.41–3.57), respectively. The pooled OR (studies n = 5) of incidence of total side effects was 0.32 (95 % CI 0.13–0.79), with significant heterogeneity observed (I 2 = 71.9 %). Conclusion: Probiotics supplementation in triple therapy for H. pylori infection may have beneficial effects on eradication and therapy-related side effects, particularly diarrhea, in children.


Helicobacter pylori Eradication Probiotics Children 


Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Shan Li
    • 1
  • Xiu-li Huang
    • 1
  • Jing-zhe Sui
    • 1
  • Si-yuan Chen
    • 2
  • Yan-tong Xie
    • 3
  • Yan Deng
    • 1
  • Jian Wang
    • 1
  • Li Xie
    • 1
  • Tai-jie Li
    • 1
  • Yu He
    • 1
  • Qi-liu Peng
    • 1
  • Xue Qin
    • 1
  • Zhi-yu Zeng
    • 4
  1. 1.Department of Clinical LaboratoryFirst Affiliated Hospital of Guangxi Medical UniversityNanningChina
  2. 2.Guangxi University of Chinese MedicineNanningChina
  3. 3.Guangxi Medical UniversityNanningChina
  4. 4.Department of GeriatricsFirst Affiliated Hospital of Guangxi Medical UniversityNanningChina

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