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Immunization status in children with inflammatory bowel disease

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Abstract

Inflammatory bowel diseases have an increased risk of infections due to immunosuppressive therapies. To report the immunization status according to previous recommendations and the reasons explaining a delay, a questionnaire was filled in by the pediatric gastroenterologist, concerning outpatients, in six tertiary centers and five local hospitals, in a study, from May to November 2011. One hundred and sixty-five questionnaires were collected, of which 106 Crohn's diseases, 41 ulcerative colitis, and 17 indeterminate colitis. Sex ratio was 87:78 M/F. Median age was 14.4 years old (4.2–20.0). One hundred and nine patients (66 %) were receiving or had received an immunosuppressive therapy (azathioprine, infliximab, methotrexate, or prednisone). Vaccines were up to date according to the vaccine schedule of French recommendations in 24 % of cases and according to the recommendations for inflammatory bowel disease in 4 % of cases. Coverage by vaccine was the following: diphtheria–tetanus–poliomyelitis 87 %, hepatitis B 38 %, pneumococcus 32 %, and influenza 22 %. Immunization delay causes were as follows: absence of proposal 58 %, patient refusal 41 %, fear of side effects 33 %, and fear of disease activation 5 %. Therefore, immunization coverage is insufficient in children with inflammatory bowel disease, due to simple omission or to refusal. A collaboration with the attending physicians and a targeted information are necessary.

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Acknowledgments

Jean‐Francois Segura, Laure Bridoux, Gaelle Le Henaff, Benoit Cagnard, Agathe Jobert, Joel Cardonna, Isabelle Grimal, Martine Balençon, Estelle Darviot, Nadege Delaperrière, Dominique Caldari and Hugues Piloquet are responsible for patient screening and enrollment.

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Authors and Affiliations

  1. Department of Pediatrics, South Hospital, CHU Rennes, 16 Boulevard de Bulgarie, BP 90347, 35203, Rennes, Cedex, France

    Romain Longuet, Estelle Breton, Laure Bridoux, Martine Balençon & Alain Dabadie

  2. Department of Pediatrics, Clocheville Hospital, CHU Tours, 49 Boulevard Béranger, 37044, Tours, Cedex, France

    Stephanie Willot

  3. Department of Pediatrics, CHU Angers, 4 Rue Larrey, 49033, Angers, Cedex 01, France

    Jean-Louis Giniès & Estelle Darviot

  4. Department of Pediatrics, CH Le Mans, 194, Avenue Rebillard, 72037, Le Mans, France

    Cecile Pélatan

  5. Department of Pediatrics, Y. Le Foll Hospital, CH Saint Brieuc, 10 Rue M. Proust, 22000, Saint Brieuc, France

    Estelle Breton

  6. Department of Pediatrics, Morvan Hospital, CHU Brest, 2 Avenue Foch, 29609, Brest, France

    Jean-François Segura & Nadège Delaperrière

  7. Department of Pediatrics, CHU Nantes, 1 Place Alexis Ricordeau, 44000, Nantes, France

    Gaelle Le Henaff, Dominique Caldari & Hugues Piloquet

  8. Department of Pediatrics, Bretagne Atlantique Hospital, CH Auray-Vannes, Boulevard du Général Guillaudot, 56017, Vannes Cedex, France

    Benoit Cagnard

  9. Department of Pediatrics, CH Saint-Nazaire, Boulevard de l’hôpital, 44600, Saint Nazaire, France

    Agathe Jobert

  10. Department of Pediatrics, CHU Poitiers, 2 Rue de la Milétrie, BP 577, 86 021, Poitiers Cedex, France

    Joël Cardonna

  11. Department of Pediatrics, CH Cholet, 1 Rue Marengo, 49325, Cholet Cedex, France

    Isabelle Grimal

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  1. Romain Longuet
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  2. Stephanie Willot
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  3. Jean-Louis Giniès
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  6. Jean-François Segura
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  7. Laure Bridoux
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  10. Agathe Jobert
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  11. Joël Cardonna
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  12. Isabelle Grimal
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  13. Martine Balençon
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  14. Estelle Darviot
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  15. Nadège Delaperrière
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  16. Dominique Caldari
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  17. Hugues Piloquet
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  18. Alain Dabadie
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Correspondence to Romain Longuet.

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Longuet, R., Willot, S., Giniès, JL. et al. Immunization status in children with inflammatory bowel disease. Eur J Pediatr 173, 603–608 (2014). https://doi.org/10.1007/s00431-013-2207-0

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  • DOI: https://doi.org/10.1007/s00431-013-2207-0

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