Pseudothrombocytopenia in a neonate due to mother?
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Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy. Conclusion: Although maternal–neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.
KeywordsPseudothrombocytopenia EDTA-dependent PTCP Neonate EDTA
- 5.Froom P, Barak M (2011) Prevalence course of pseudothombocytopenia in outpatients. Clin Chem Labmed 49:111–114Google Scholar
- 6.Jacobs J, Tricot G, Verwilghen RL (1986) Pseudotrombocytopenie door trombocytenagglutinaten (EDTA-pseudotrombocytopenie). Ned Tijdschrift voor Geneeskunde 130:1643–1646Google Scholar