European Journal of Pediatrics

, Volume 172, Issue 7, pp 987–989 | Cite as

Pseudothrombocytopenia in a neonate due to mother?

  • J. J. Korterink
  • B. Boersma
  • M. Schoorl
  • L. Porcelijn
  • P. C. M. Bartels
Case Report


Ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a false low platelet count reported by an automated haematology analyzer due to in vitro aggregation of platelets. This aggregation is due to the interaction between antibodies and EDTA-dependent crypt antigens on platelets. We observed a new born child whose mother was diagnosed with transient PTCP due to transplacental transmission of maternal immunoglobulin G antibodies during pregnancy. Conclusion: Although maternal–neonatal PTCP is rare, it is important to consider this phenomenon as a cause of trombocytopenia, as it can result in unnecessary diagnostic workup and treatment.


Pseudothrombocytopenia EDTA-dependent PTCP Neonate EDTA 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • J. J. Korterink
    • 1
    • 4
  • B. Boersma
    • 1
  • M. Schoorl
    • 2
  • L. Porcelijn
    • 3
  • P. C. M. Bartels
    • 2
  1. 1.Department of PaediatricsMedical Center AlkmaarAlkmaarNetherlands
  2. 2.Department of Clinical Chemistry, Haematology and ImmunologyMedical Center AlkmaarAlkmaarThe Netherlands
  3. 3.Sanquin Diagnostic ServicesAmsterdamThe Netherlands
  4. 4.Department of PaediatricsJeroen Bosch HospitalHertogenboschThe Netherlands

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