Incomplete clinical manifestation as a risk factor for coronary artery abnormalities in Kawasaki disease: a meta-analysis
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Incomplete Kawasaki disease (KD) comprises a large proportion of the total number of cases. Although it has the potential of delaying diagnosis, it is not conclusive whether an incomplete presentation is a risk factor for coronary artery abnormalities (CAAs). We performed a meta-analysis to establish the risk of CAA in 20 studies including 4,504 cases and 32,519 controls, and the risk of giant aneurysm in two studies including 5,390 cases and 37,648 controls. The pooled results indicated that incomplete KD was associated with an increased risk of CAA [odds ratio (OR) = 1.447, 95 % confidence interval (CI) = 1.158–1.808, p = 0.001]. Subgroup analyses demonstrated higher associations in patients younger than 12 months (OR = 2.023, 95 % CI = 1.252–3.271, p = 0.004), Asians and Indians (OR = 1.57, 95 % CI = 1.234–1.999, p < 0.001 and OR = 7.088, 95 % CI = 1.640–30.631, p = 0.009, respectively). Subgroup analysis according to the period of patient enrollment before and after 2004 showed increased association of incomplete KD with CAA only among studies with patients enrolled after 2004 (OR = 1.969, 95 % CI = 1.240–3.127, p = 0.004). In conclusion, incomplete KD seems to be associated with an increased risk of CAA, and this is more prominent in patients younger than 12 months, Asians and Indians.
KeywordsAneurysm Coronary artery abnormality Kawasaki disease–incomplete Meta-analysis
This study was supported by Hin Moe fund (Dr. Hyun-Gum Lee).
Conflict of interest
We have no conflict of interest to declare.
- 7.Ghelani SJ, Sable C, Wiedermann BL, Spurney CF (2012) Increased incidence of incomplete Kawasaki disease at a pediatric hospital after publication of the 2004 American Heart Association Guidelines. PediatrCardiol 33(7):1097–103Google Scholar
- 9.Japan Kawasaki Disease Research Committee (1984) Diagnostic guidelines of Kawasaki disease. 4th rev. Japan Kawasaki Disease Research Committee, TokyoGoogle Scholar
- 17.Newburger JW, Takahashi M, Gerber MA, Gewitz MH, Tani LY, Burns JC, Shulman ST, Bolger AF, Ferrieri P, Baltimore RS, Wilson WR, Baddour LM, Levison ME, Pallasch TJ, Falace DA, Taubert KA (2004) Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 110(17):2747–2771PubMedCrossRefGoogle Scholar