The role of enzyme replacement therapy in severe Hunter syndrome—an expert panel consensus

Abstract

Intravenous enzyme replacement therapy (ERT) with idursulfase for Hunter syndrome has not been demonstrated to and is not predicted to cross the blood–brain barrier. Nearly all published experience with ERT with idursulfase has therefore been in patients without cognitive impairment (attenuated phenotype). Little formal guidance is available on the issues surrounding ERT in cognitively impaired patients with the severe phenotype. An expert panel was therefore convened to provide guidance on these issues. The clinical experience of the panel with 66 patients suggests that somatic improvements (e.g., reduction in liver volume, increased mobility, and reduction in frequency of respiratory infections) may occur in most severe patients. Cognitive benefits have not been seen. It was agreed that, in general, severe patients are candidates for at least a 6–12-month trial of ERT, excluding patients who are severely neurologically impaired, those in a vegetative state, or those who have a condition that may lead to near-term death. It is imperative that the treating physician discuss the goals of treatment, methods of assessment of response, and criteria for discontinuation of treatment with the family before ERT is initiated. Conclusion: The decision to initiate ERT in severe Hunter syndrome should be made by the physician and parents and must be based on realistic expectations of benefits and risks, with the understanding that ERT may be withdrawn in the absence of demonstrable benefits.

Introduction

The development of therapies for rare complex diseases, with their associated high price, has raised many questions and concerns related to pharmacoeconomics and societal desires to meet the particular needs of patients with rare diseases. Enzyme replacement therapy (ERT) has become a standard of care for patients with several lysosomal storage disorders [12, 15, 25, 36], but because of disease heterogeneity, particularly in the mucopolysaccharidoses, there is disagreement as to the role that such treatments play for the severely affected patients as well as patients who are at the end stages of disease.

Hunter syndrome (mucopolysaccharidosis II, OMIM 309900) is one of these mucopolysaccharidoses [17] for which a specific, targeted treatment, ERT with idursulfase (Elaprase®, Shire Human Genetic Therapies, Inc., Cambridge, MA, USA), has been developed [25]. Approximately two thirds of the patients with this condition will develop progressive neurodegeneration [24], ultimately affecting cognitive function and limiting lifespan. Intravenous administration of ERT does not allow for sufficient enzyme to cross the blood–brain barrier and reach the central nervous system, yet some physicians and families have seen benefits to its use in these severe patients for the improvement or stabilization of some somatic signs and symptoms.

The present manuscript is based on discussions of an international panel of physicians experienced in the management and treatment of patients with Hunter syndrome. This group was convened in mid-2008 by Shire Human Genetic Therapies, Inc. (Cambridge, MA, USA) to discuss issues surrounding the use of idursulfase in Hunter patients with the severe phenotype. This manuscript follows two previous papers on diagnosis and management of Hunter syndrome that were developed in a similar fashion [17, 26].

Hunter syndrome overview

Hunter syndrome (mucopolysaccharidosis II, MPS II) is a rare, X-linked metabolic disease that is caused by a deficiency of the lysosomal enzyme, iduronate-2-sulfatase (I2S) [1, 27]. This enzyme catalyzes the removal of sulfate at the 2 position of l-iduronic acid present at the nonreducing end of the glycosaminoglycans (GAG) dermatan sulfate and heparan sulfate. In Hunter syndrome patients, these substrates accumulate both intracellularly and extracellularly and, through poorly understood mechanisms, lead to the clinical features of the disease. Over 300 mutations in the gene encoding iduronate-2-sulfatase have been described, many of which represent private or nonrecurrent mutations. There is no evidence of significant disease modifiers, and thus the heterogeneity of the disease phenotype (see below) is believed to be related to the amount and activity of residual enzyme conferred by the mutation. As such, deletions and gene rearrangements, which account for up to 25% of Hunter syndrome cases, always result in a severe phenotype [10, 13, 16, 22, 32].

General phenotype

The phenotypic expression of Hunter syndrome has recently been described in detail [17, 37]. MPS II affects multiple organs and systems with a variable age of onset of signs and symptoms and a variable rate of progression. The clinical spectrum of Hunter syndrome spans a wide range, from an attenuated to a severe phenotype [27]. Patients usually appear normal at birth, but in the most severely affected patients, signs and symptoms typically begin to appear between 2 and 4 years of age. All affected patients, including those with an attenuated phenotype, experience progressive somatic involvement, including enlarged liver and spleen, skeletal and joint involvement resulting in reduced joint range of motion and contractures, and heart and airway disease [17, 27, 37]. In addition, patients with the severe phenotype experience profound neurological involvement that results in severe cognitive impairment, progressive neurodegeneration, and death in the second decade of life [17, 41, 42]. Patients with an attenuated phenotype demonstrate normal intelligence and usually survive into adulthood, although shortened life span is seen [40]. The prediction of an attenuated or severe phenotype is difficult early in the course of the disease for many patients.

Severe Hunter syndrome

Severe Hunter syndrome is the description used to refer to patients who demonstrate progressive central nervous system involvement with early cognitive impairment. It has been estimated that about two thirds of patients are destined to have a severe phenotype [7, 24, 32]. Patients with a severe phenotype typically have an earlier onset of signs and symptoms—age 2 to 4 years—than is seen with the attenuated phenotype [42]. The profound cognitive impairment results in delayed developmental milestones, with an onset in early childhood. Developmental skills plateau between 4 and 6 years of age and decline thereafter. These patients often exhibit severe behavioral problems, including hyperactivity, obstinacy, and aggression, beginning in the second year of life and continuing to late childhood [39]. Behavior may later appear to improve, with a decrease in hyperactivity and aggression, but this change is due to continuing neurodegeneration [39]. Late-stage disease is characterized by a neurodegenerative state often associated with seizures and lack of mobility [41]. Communicating hydrocephalus with increased intracranial pressure may contribute to the behavioral problems, as well as seizures [33, 38].

Management and treatment of severe Hunter syndrome

Historically, the management of Hunter syndrome was directed to the specific disease symptoms and complications, regardless of the phenotype [23, 24]. For example, surgery may be required to relieve respiratory obstruction caused by enlarged tonsils and adenoids. As emphasized in a recent review, the management of Hunter syndrome is never routine, and because of the progressive multisystem involvement, management always requires a multidisciplinary and anticipatory approach [24].

Recombinant human I2S (idursulfase, Elaprase®, Shire Human Genetic Therapies, Inc., Cambridge, MA, USA) was approved for the treatment of Hunter syndrome in 2006 and is available in the United States, European Union, and other countries. Idursulfase is administered intravenously on a weekly basis in the hospital setting. Some Hunter syndrome patients have been reported to have received infusions at home; this is only undertaken after a lengthy screening process and is not available in all countries [2–4, 14, 21]. The approval of idursulfase was based on data from the pivotal clinical trial, which demonstrated that 1 year of weekly infusions of 0.5 mg/kg significantly improved the primary endpoint, a composite comprising changes in distance walked in 6 min and changes in percent-predicted forced vital capacity (FVC) compared to placebo [25]. Other improvements included reduction in urinary GAG excretion, reduction in liver and spleen volume, and improvements in absolute FVC.

No severely affected patients were included in the pivotal trial because of their inability to perform pulmonary function testing or the 6-min walk test, the two components of the composite end point. Because a significant amount of enzyme has not been demonstrated to and is not predicted to cross the blood–brain barrier, clinical improvement of central neurological involvement in patients with the severe phenotype is not expected. Severely affected patients would be expected to experience somatic improvement with idursulfase treatment, however, but no clinical studies of ERT in severe Hunter patients have been conducted and only a few case reports have been published (e.g., [8, 28]).

Hematopoietic stem cell transplantation (HSCT) has become the treatment of choice for the severe form of mucopolysaccharidosis I (Hurler syndrome), in which successful transplantation can preserve neurocognition, improve some aspects of the somatic disease, and markedly increase survival [24, 36]. There is little evidence to support the use of HSCT in Hunter syndrome, however. To date, only small case series have been reported. These indicate that HSCT results in stabilization or improvement in some somatic manifestations of Hunter syndrome, as seen with recombinant ERT, but little or no cognitive benefit has been demonstrated [11, 20, 29, 35].

Enzyme replacement therapy in severe Hunter syndrome

The authors have had experience with the use of idursulfase in 66 Hunter syndrome patients with the severe phenotype. All of these patients, who were 2 to 24 years old, experienced the somatic manifestations of Hunter syndrome and demonstrated variable aspects of cognitive involvement, including loss of speech, behavioral issues, and developmental degeneration. After at least 1 year of ERT, 50 out of 66 patients experienced at least one type of somatic improvement, such as a reduction in the frequency of respiratory infections, a reduction in the coarseness of facial features, improved joint range of motion, or improved sleep apnea. It is the opinion of the authors that the younger patients responded better than older patients. Nearly all of the patients displayed a reduction in liver volume (61 of 66). Improvements in hepatomegaly are clinically relevant in that they may improve overall patient comfort from symptoms such as dyspnea, early satiety, or gastroesophageal reflux. In addition, a sustained reduction in liver volume is a clinical biomarker that can be used to reflect the activity of ERT. Parent-reported- and/or physician-observed improvement in mobility was noted in 35 out of 66. None of the patients could be described as experiencing a direct effect on cognitive function as a result of ERT. In some cases, an improvement in behavior was noted by the family, but this may have reflected improvements in general health and quality of life resulting from somatic improvements. Thirty-one patients experienced an infusion reaction during treatment, which was managed by slowing or stopping the infusion and pretreatment with an antihistamine and/or corticosteroid prior to subsequent infusions. Sufficient benefit to continue ERT was determined to be present in 61 out of 66 patients. In five cases, the lack of clinical benefit resulted in the decision to withdraw ERT.

Discussion and commentary

During the meeting of the expert panel, important clinical and ethical issues concerning the use of ERT in severe Hunter patients were discussed. These issues included: (1) which patients should be considered candidates for the initiation of ERT, (2) treatment goals, (3) assessing response to ERT, (4) when to discontinue ERT, (5) the development of guidelines about ERT in severe Hunter syndrome, and (6) the role of government and health reimbursement agencies in the determination of eligibility for ERT in severe Hunter syndrome.

Initiation of ERT in severe Hunter syndrome

The decision to initiate ERT in a patient with severe Hunter syndrome must be made with the disease stage in mind. If the patient is newly diagnosed, they should be offered treatment, even if the rate of cognitive decline or severity of their eventual cognitive phenotype is not yet apparent. Hunter syndrome is a progressive disease that affects multiple systems and results in irreversible organ damage over time. Both patients with attenuated disease (cognitively intact) and those with severe disease (cognitively impaired) experience many somatic signs and symptoms that can reduce quality of life, including hepatosplenomegaly, impaired respiratory function, sleep apnea, frequent infections, and joint pain [17, 27, 37]. Therefore, withholding a therapeutic that has the potential to improve some of the somatic manifestations of the disease because of an eventual cognitive decline is not justifiable in the newly diagnosed patient.

It is the authors' opinion that all previously diagnosed, symptomatic patients in whom there is an expectation that ERT will alter the course of the somatic involvement are also candidates for a trial of idursulfase treatment, even if cognitive impairment is already evident. As with newly diagnosed patients, the somatic signs and symptoms of the disease may reduce the quality of life for both the patient as well as for the caregivers; therefore, a trial of a therapeutic that may improve some of the somatic features is justified. A critical part of the initiation process for both newly diagnosed patients and those who have been previously diagnosed is to discuss treatment goals, the evaluation of response to ERT, and the eventual discontinuation of therapy with the family at the outset (discussed in more detail below).

Not all patients with severe Hunter syndrome should be considered candidates for ERT. It is the opinion of the authors that patients who are severely neurologically impaired (such as in a vegetative state) with subsequent low expectation of benefit should not be considered for ERT. What constitutes severe neurological impairment may be the subject of some debate, but a patient who is gastrostomy fed due to an inability to swallow would likely fall into this category. Similarly, patients who have a disease manifestation or other condition that may lead to near-term death should not receive ERT.

Goals of treatment

Before beginning ERT, it is absolutely essential that the physician and family discuss the goals of treatment, expectations for response, methods for evaluating response, and criteria for discontinuing therapy. This discussion should ideally be directly between the treating physician and family. It should be emphasized in these discussions that ERT should be considered a trial and that the response to ERT will be evaluated after a minimum of 6 to 12 months. A key point that must be made is that ERT will not alter the course of the neurological decline but may produce somatic improvements, such as improved mobility, reductions in liver and spleen volumes, and reductions in respiratory infections and resultant hospitalizations. A written summary of the discussion may be helpful in managing family expectations and could include the statement that the response to ERT will be evaluated at a certain time point and that ERT may be discontinued if the physician and family agree that no benefit has been demonstrated. In the authors' opinion, a perceived improvement in the quality of life by the family should be taken into strong consideration as a reason to continue therapy even if other clinical benefits are not obvious on examination.

Parents and guardians need to be aware that not all responses may be positive. For example, infusion reactions, which typically involve pyrexia, chills, flushing, and/or headache, would be expected to occur in some patients (as they do in patients with an attenuated phenotype [25]), and the patients would not be able to articulate their symptoms during these events. It was also the experience of several members of the panel that ERT may result in worsening of behavioral problems in some severe Hunter patients.

The importance of a discussion with the family about goals and expectations cannot be understated, as these expectations play a major role in influencing their decision about whether to initiate ERT. This was recently illustrated in a survey study by Coman and colleagues [5]. In their study, 249 parents/caregivers and adult patients with an MPS disorder who were part of MPS support groups in the United States and Australia were surveyed to solicit their opinion of whether to initiate ERT based on a hypothetical phenotype and hypothetical response to ERT. For Hunter syndrome patients with a severe phenotype and with the expectation that ERT would result in minimal physical improvement, no change in cognitive involvement, and a 3-year increase in expected life span, 57% of respondents would choose to use ERT. For the same patients and same expectations, with the exception of a 15-year increase in lifespan, 79% of respondents would choose ERT. If cognitive improvement were expected, nearly all would choose ERT.

Assessment of the response to ERT

The major challenge in evaluating the response to ERT in severe Hunter patients is the lack of assessment tools that are validated in this population. For example, there is no validated instrument that can objectively measure changes in function and quality of life in cognitively impaired patients with Hunter syndrome, although the development of such an instrument is currently the object of much concerted effort. Additionally, there are no validated biomarkers that can be used to measure response to treatment, although again much research effort is currently directed towards this problem. Some physicians have attempted to use clinical trial endpoints, but these were developed for patients with no cognitive involvement. Patients with cognitive impairment are most often unable to comprehend and cooperate with testing [9]. For example, such patients cannot independently perform the 6-min walk test (6MWT), and the results of a “parent-assisted” 6MWT are not meaningful for evaluating mobility and endurance in severely affected patients and should not be used. Similarly, pulmonary function tests like the ones that were used to demonstrate the clinical efficacy of idursulfase in clinical trials require the understanding and cooperation of the patient and are beyond the capabilities of severely affected patients.

However, certain evaluations are useful in this population. The physician may be able to evaluate joint range-of-motion in the cognitively impaired patient and can note improvements in liver and spleen size, coarseness of facial features, and macroglossia on examination. Frequency of respiratory infections and resulting hospitalizations is another factor that may be quantified. Yet, assessing the response to ERT is for a large part subjective and must, by necessity, be based upon the physician's clinical impression and upon parental assessment. Certainly parents are inherently biased and may see improvement where no objective improvement exists; however, parents can report on objective milestones (e.g., getting out of bed, climbing stairs, improved appetite, etc.). In the authors' opinion, an important goal of therapy is the improvement in quality of life for the patient and family, so a perception by the family of improved quality of life should be taken into strong consideration when deciding whether or not to continue therapy.

Decision to stop ERT in severe Hunter syndrome

The use of ERT in a patient with severe Hunter syndrome should be considered a trial by both the physician and the family. Goals for treatment should have been discussed before ERT was initiated, with assessment occurring after some agreed upon time period. It is the opinion of most of the authors that 6 to 12 months should be sufficient to determine if clinical benefit is occurring [37]; however, some authors feel that up to 18 months may be needed. Included in these discussions should be the idea that ERT cannot stop the eventual neurological decline and should at some point be discontinued. Although such discussions can be difficult, it is important to convey to families that when a patient is significantly neurologically impaired, such as being gastrostomy fed due to an inability to swallow or in a vegetative state, there is little benefit to continuing with ERT. Similarly, it is the experience of the authors that occasionally a patient with severe Hunter syndrome will display exacerbated behavioral difficulties as a result of therapy; such an occurrence often reduces patient and family quality of life and can be the criterion for discontinuing ERT.

It should be pointed out that, to some families, the goal of ERT is to prolong survival no matter what is the state of the patient. In certain countries (e.g., Germany, UK, and Austria), ERT would currently be continued if the parents insisted, despite the apparent lack of response. In certain provinces of Canada, neurological deterioration and loss of independent functioning could be the basis for discontinuation of treatment. Comprehensive guidelines are needed to help guide these decisions and are currently in development.

Guidelines for ERT in severe Hunter syndrome

Guidelines for the use of idursulfase in the treatment of Hunter syndrome have been published for Australia [18] and UK [34] and are being developed in other countries and regions. As expected, treatment guidelines will differ among countries. For example, in the UK, all patients with a documented I2S deficiency are eligible to receive idursulfase regardless of phenotype, whereas in Australia only patients with an attenuated phenotype are considered eligible for treatment. The Australian guidelines allow the treatment of young patients before the phenotype can be determined, but stipulate that ERT is to be withdrawn if neurological involvement becomes evident. To date, guidelines specific to treatment of severe Hunter syndrome patients have not been published for any other country.

Role of government and health reimbursement agencies

The policies of the local health care system may influence the decision about which severe Hunter patients might receive ERT. For example, in the UK all patients with documented I2S deficiency are eligible for ERT, regardless of phenotype [34]. Similarly, in Germany, all patients would be offered treatment (Michael Beck, personal communication). In Canada, the decision about ERT would be made on a case-by-case evaluation and would depend on the level of funding for ERT in the individual provinces. For example, in Canada, a predictably severe patient (i.e., has a complete deletion of the gene) under the age of 5 years would likely be treated, but an older patient who presents clear evidence of neurodegeneration would not (Lorne Clarke, personal communication). In the United States, the decisions are made by the individual physicians and the patient's families or guardians. In any situation, it is important that the ultimate decision be made jointly by the physician and the family.

Governments and reimbursement agencies are increasingly using pharmacoeconomic analyses to guide decisions about the use and funding of new drugs or treatments. No cost-effectiveness study of ERT in Hunter syndrome has been published. In the cases of Fabry disease [6, 21] and MPS VI [30], traditional analyses based on the cost per quality-adjusted life year have failed to demonstrate cost-effectiveness of ERT. The societal and ethical considerations of funding ERT for lysosomal storage diseases have been studied, but no consensus has emerged about methods of funding ERT. It must be understood that these diseases are extremely rare, and although ERT is expensive, the overall cost to a government or reimbursement agency is small compared with their total health care expenditures.

Summary

The decision regarding the use of ERT in Hunter disease patients with a severe phenotype is complex and based on many considerations, including the clinical status of the patient, the expectation of benefit, and the risks associated with ERT. The authors' clinical experiences in treating severe Hunter patients have been generally positive, but the decision to initiate and possibly stop ERT needs to be individualized based on the considerations noted above.