European Journal of Pediatrics

, Volume 169, Issue 12, pp 1549–1551 | Cite as

Too much of too little: xylitol, an unusual trigger of a chronic metabolic hyperchloremic acidosis

  • David Wille
  • Mathias Hauri-Hohl
  • Priska Vonbach
  • Maren Tomaske
  • Beth Padden
  • Vera Bernet
Short Report

Abstract

Homeopathic globules are frequently used in children as a first-line treatment. Most of these globules are coated with sugar substitutes like xylitol; these substitutes are known for their laxative effect. Our patient shows that consumption of globules coated with xylitol does not have only laxative effects. It may cause indeed considerable weight loss and life-threatening enteral bicarbonate loss by diarrhea when overdosed in an infant.

Keywords

Children Metabolic acidosis Xylitol Enteral bicarbonate loss 

References

  1. 1.
    Ly KA, Milgrom P, Rothen M (2008) The potential of dental-protective chewing gum in oral health interventions. J Am Dent Assoc 139:553–563PubMedGoogle Scholar
  2. 2.
    Menniti-Ippolito F, Mazzanti G, Santuccio C et al (2008) Surveillance of suspected adverse reactions to natural health products in Italy. Pharmacoepidemiol Drug Saf 17:626–635CrossRefPubMedGoogle Scholar
  3. 3.
    Salminen E, Salminen S, Porkka L et al (1989) Xylitol vs. glucose: effect on the rate of gastric emptying and motilin, insulin, and gastric inhibitory polypeptide release. Am J Clin Nutr 49:1228–1232PubMedGoogle Scholar
  4. 4.
    Tsuneyuki OT, Nakamura S (2007) Threshold for transitory diarrhea induced by ingestion of xylitol und lactitol in young male and female adults. J Nutr Sci Vitaminol 53:13–20CrossRefGoogle Scholar
  5. 5.
    Vernacchio L, Vezina RM, Mitchell AA (2007) Tolerability of oral xylitol solution in young children: implications for otitis media prophylaxis. Int J Pediatr Otorhinolaryngol 71:89–94CrossRefPubMedGoogle Scholar
  6. 6.
    Wang Y-M, van Eys J (1981) Nutritional significance of fructose and sugar alcohols. Annu Rev Nutr 1:437–447CrossRefPubMedGoogle Scholar
  7. 7.
    Zuzak T, Rauber-Lüthy C, Simoes-Wüst A (2010) Accidental intakes of remedies from complementary and alternative medicine in children—analysis of data from the Swiss Toxicological Information Centre. Eur J Pediatr 169:681–688CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • David Wille
    • 1
  • Mathias Hauri-Hohl
    • 1
  • Priska Vonbach
    • 2
  • Maren Tomaske
    • 3
  • Beth Padden
    • 1
  • Vera Bernet
    • 1
  1. 1.Department of Intensive Care and NeonatologyUniversity Children’s HospitalZurichSwitzerland
  2. 2.Department of Hospital PharmacyUniversity Children’s HospitalZurichSwitzerland
  3. 3.Department of PediatricsTriemli Hospital ZurichZurichSwitzerland

Personalised recommendations