European Journal of Pediatrics

, Volume 169, Issue 11, pp 1317–1322 | Cite as

Thalassemia and iron deficiency in a group of northeast Thai school children: relationship to the occurrence of anemia

  • Nichathorn Panomai
  • Kanokwan Sanchaisuriya
  • Supawadee Yamsri
  • Pattara Sanchaisuriya
  • Goonnapa Fucharoen
  • Supan Fucharoen
  • Frank P. Schelp
Original Paper

Abstract

The cross-sectional study assessed anemia, thalassemia, and hemoglobinopathies, as well as iron deficiency, among 190 northeastern Thai school children aged 10 to 11 years. The aim was to analyze the reasons for anemia among the group. Hemoglobin concentration and other hematological parameters were determined using an automated blood cell counter. Beta-thalassemia and other hemoglobinopathies were identified by high performance liquid chromatography (HPLC) analysis of hemoglobin. Alpha-thalassemia was identified by polymerase chain reaction (PCR) and related techniques. Iron deficiency was assessed using serum ferritin (SF) <20 ng/ml as indicator. Based on the WHO criteria, anemia was defined by hemoglobin (Hb) level <11.5 g/dl. Twenty five out of 190 children (13.2%; 95% CI = 8.7–18.8%) were anemic. Iron deficiency was found in only two out of 190 children (1.0%; 95% CI = 0.1–3.8%), but the two iron deficient children were not anemic. The proportion of thalassemia and hemoglobinopathies among the group was 61.1% (95% CI = 53.7–68.0%). As underlying reasons for anemia, thalassemia and hemoglobinopathies were found in 22 out of 25 (88.0%) anemic children. Beta-thalassemia and homozygous Hb E seem to be important, while this was less obvious for heterozygous α-thalassemia and heterozygous Hb E. Conclusion: The results suggest that thalassemia and hemoglobinopathies may be major contributing factors to the occurrence of anemia in this area among the children’s population.

Keywords

Thalassemia Hemoglobinopathies Iron deficiency Anemia School children 

Abbreviations

SF

Serum ferritin

CI

Confidence interval

Rbc

Red blood cell

Hb

Hemoglobin

MCV

Mean corpuscular volume

MCH

Mean corpuscular hemoglobin

MCHC

Mean corpuscular hemoglobin concentration

RDW

Red blood cell distribution width

Notes

Acknowledgments

The study was supported in part by grants from the Graduate School, Khon Kaen University, and Office of the Higher Education Commission, Ministry of Education, Thailand. We would like to thank the directors and teachers of four schools; Choomchon Ban Wang Perm, Nong Ta Kai Pittaya, Ban Mai Sok Som Kob, and Si Chomphu Kindergarten school, Khon Kaen province, Thailand. Thanks to Dr. Ian Thomas for correcting the English.

Conflict of interest

None.

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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Nichathorn Panomai
    • 1
    • 2
  • Kanokwan Sanchaisuriya
    • 3
  • Supawadee Yamsri
    • 1
    • 3
  • Pattara Sanchaisuriya
    • 2
  • Goonnapa Fucharoen
    • 3
  • Supan Fucharoen
    • 3
  • Frank P. Schelp
    • 2
  1. 1.Graduate SchoolKhon Kaen UniversityKhon KaenThailand
  2. 2.Department of NutritionKhon Kaen UniversityKhon KaenThailand
  3. 3.Centre for Research and Development of Medical Diagnostic LaboratoriesKhon Kaen UniversityKhon KaenThailand

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