European Journal of Pediatrics

, Volume 169, Issue 12, pp 1439–1444 | Cite as


Sweet syndrome


Sweet syndrome, also referred to as acute febrile neutrophilic dermatosis, is characterized by tender, red inflammatory nodules or papules that occur in association with infection, malignancy, connective tissue disease, or following exposure to certain drugs. Although drug-induced Sweet syndrome is rare, granulocyte colony-stimulating factor, all-trans-retinoic acid, and miscellaneous drugs have been implicated in causing this disorder in adults. In pediatric patients, granulocyte colony-stimulating factor, all-trans-retinoic acid, trimethoprim-sulfamethoxazole, and azathioprine have been implicated as potential causes of drug-induced Sweet syndrome. To date, six cases, including the patient reported here, have been reported in children.


Sweet syndrome Drug induced Children 



Sweet syndrome


c-type anti-neutrophil cytoplasmic antibody


Thiopurine methyltransferase


Granulocyte colony-stimulating factor



There was no grant support for this article.

Conflict of interests



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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  1. 1.Department of PediatricsSamsung Medical Center, Sungkyunkwan University School of MedicineSeoulSouth Korea

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