References
Broeckaert F, Clippe A, Knoops B, Hermans C, Bernard A (2000) Clara cell secretory protein (CC16): features as a peripheral lung biomarker. Ann N Y Acad Sci 923:68–77
Chandra S, Davis JM, Drexler S, Kowalewska J, Chester D, Koo HC, Pollack S, Welch R, Pilon A, Levine CR (2003) Safety and efficacy of intratracheal recombinant human Clara cell protein in a newborn piglet model of acute lung injury. Pediatr Res 54:509–515
Dreyfuss D, Saumon G (1998) Ventilator-induced lung injury: lessons from experimental studies. Am J Respir Crit Care Med 157:294–323
Hermans C, Knoops B, Wiedig M, Arsalane K, Toubeau G, Falmagne P, Bernard A (1999) Clara cell protein as a marker of Clara cell damage and bronchoalveolar blood barrier permeability. Eur Respir J 13:1014–1021
Johnston CJ, Mango GW, Finkelstein JN, Stripp BR (1997) Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. Am J Respir Cell Mol Biol 17:147–155
Jorens PG, Sibille Y, Goulding NJ, van Overveld FJ, Herman AG, Bossaert L, De Backer WA, Lauwerys R, Flower RJ, Bernard A (1995) Potential role of Clara cell protein, an endogenous phospholipase A2 inhibitor, in acute lung injury. Eur Respir J 8:1647–1653
Lassus P, Nevalainen TJ, Eskola JU, Andersson S (2000) Clara-cell secretory protein in preterm infants’ tracheal aspirates correlates with maturity and increases in infection. Pediatr Pulmonol 30:466–469
Levine CR, Gewolb IH, Allen K, Welch RW, Melby JM, Pollack S, Shaffer T, Pilon AL, Davis JM (2005) The safety, pharmacokinetics, and anti-inflammatory effects of intratracheal recombinant human Clara cell protein in premature infants with respiratory distress syndrome. Pediatr Res 58:15–21
Ramsay PL, DeMayo FJ, Hegemier SE, Wearden ME, Smith CV, Welty SE (2001) Clara cell secretory protein oxidation and expression in premature infants who develop bronchopulmonary dysplasia. Am J Respir Crit Care Med 164:155–161
Sarafidis K, Stathopoulou T, Diamanti E, Soubasi V, Agakidis C, Balaska A, Drossou V (2008) Clara cell secretory protein (CC16) as peripheral blood biomarker of lung injury in ventilated preterm neonates. Eur J Pediatr (in press)
Schrama AJ, Bernard A, Poorthuis BJ, Zwinderman AH, Berger HM, Walther FJ (2008) Cord blood Clara cell protein CC16 predicts development of bronchopulmonary dysplasia. Eur J Pediatr (in press)
Wang SZ, Rosenberger CL, Bao YX, Stark JM, Harrod KS (2003) Clara cell secretory protein modulates lung inflammatory and immune responses to respiratory syncytial virus infection. J Immunol 171:1051–1060
Welty SE (2005) CC10 administration to premature infants: in search of the “silver bullet” to prevent lung inflammation. Pediatr Res 58:7–9
Yoshikawa S, King JA, Reynolds SD, Stripp BR, Parker JC (2004) Time and pressure dependence of transvascular Clara cell protein, albumin, and IgG transport during ventilator-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 286:L604–L612
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Greenough, A. Clara cell secretory protein and bronchopulmonary dysplasia in prematurely born infants. Eur J Pediatr 167, 1347–1348 (2008). https://doi.org/10.1007/s00431-008-0746-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00431-008-0746-6