Abstract
We describe a female infant with bilateral facial paralysis and abducens palsy. To the best of our knowledge, this is the first report of Moebius syndrome presenting with congenital bilateral vocal cord paralysis (CBVCP). Although CBVCP can be part of a recognizable syndrome, i.e. Down syndrome, 22q deletion syndrome, Robinow’s syndrome and cerebro-oculo-facio-skeletal syndrome, no reports of Moebius syndrome with CBVCP were found in the literature. CBVCP is often associated with central nervous system abnormalities. However, our patient had no detectable brain abnormalities. The etiology of Moebius syndrome remains unknown. It is interesting that the clinical manifestations of Moebius syndrome can include CBVCP. However, the pathophysiology of CBVCP is unknown and further investigations into the etiology of Moebius syndrome are required.
Similar content being viewed by others
Abbreviations
- AEDs:
-
antiepileptic drugs
- BVCP:
-
bilateral vocal cord paralysis
- CBVCP:
-
congenital bilateral vocal cord paralysis
- ZNS:
-
zonisamide
References
Berkowitz RG (2003) Congenital bilateral adductor vocal cord paralysis. Ann Otol Rhinol Laryngol 112:764–767
Berkowitz RG, Bankier A, Moxham JP, Gardner RJ (2001) Chromosomal abnormalities in idiopathic congenital bilateral vocal cord paralysis. Ann Otol Rhinol Laryngol 110:624–626
D’Cruz OF, Swisher CN, Jaraden S, Tang T, Konkol RJ (1993) Möbius syndrome: evidence for a vascular etiology. J Child Neurol 8:260–265
Gulcan H, Onal C, Arslan S, Bayindir T (2005) Bilateral vocal cord paralysis in newborns with neuraxial malformations. Neurol Med Chir 45:536–539
Kondo T (1991) Antiepileptic drug therapy and reductive consequence: functional and morphologic effects. Reprod Toxicol 5:179–188
Kondo T, Kaneko S, Amano Y, Egawa I (1996) Preliminary report on teratogenic effects of zonisamide in the offspring of treated women with epilepsy. Epilepsia 37:1242–1244
Kumar D (1990) Moebius syndrome. J Med Genet 27:122–126
Möbius PJ (1888) Über angeborene doppelseitige Abducens-Facialis Lahmung. Munch Med Wochenschr 35:91–94
Raza SA, Mahendran S, Rahman N, Williams RG (2002) Familial vocal fold paralysis. J Laryngol Otol 116(12):1047–1049
Sanchez O, Guerra D (2003) Moebius syndrome due to the use of misoprostol. Invest Clin 44:147–153
Verzijl HT, van der Zwaag B, Cruysberg JR, Padberg GW (2003) Mobius syndrome redefined: a syndrome of rhombencephalic maldevelopment. Neurology 61:327–333
Voirin J, Laloum D, Bonte JB, Eckart P, Ouedru-Aboane J, Valdazo A (1991) Moebius syndrome with pharyngo-laryngeal paralysis in a premature infant. Arch Fr Pediatr 48:35–37
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kanemoto, N., Kanemoto, K., Kamoda, T. et al. A case of Moebius syndrome presenting with congenital bilateral vocal cord paralysis. Eur J Pediatr 166, 831–833 (2007). https://doi.org/10.1007/s00431-006-0333-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00431-006-0333-7