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Successful unrelated bone marrow transplantation in a child with chronic granulomatous disease complicated by pulmonary and cerebral granuloma formation

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Abstract

We report on a 6-year-old boy with chronic granulomatous disease (CGD) complicated by chronic inflammatory reactions with formation of large pulmonary granuloma as well as intracerebral lesions. Bone marrow transplantation (BMT) from an unrelated donor led to stable reconstitution, to rapid resolution of pulmonary granuloma, and to rapid resolution of intracerebral lesions.

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Abbreviations

BMT:

bone marrow transplantation

CGD:

chronic granulomatous disease

CT:

computer tomography

gp91phox :

glycoprotein-91-phosphatase

GvHD:

graft-versus-host disease

MRI:

magnetic resonance imaging

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Authors and Affiliations

  1. Department of Pediatrics, University of Ulm, Eythstrasse 24, 89073, Ulm, Germany

    Catharina Schuetz, Manfred Hoenig, Ansgar Schulz & Wilhelm Friedrich

  2. Department of Pediatrics, Technical University of Dresden, Dresden, Germany

    Min Ae Lee-Kirsch, Joachim Roesler & Horst von Bernuth

  3. Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes-INSERM U550, Necker Medical School, 75015, Paris, France

    Horst von Bernuth

Authors
  1. Catharina Schuetz
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  2. Manfred Hoenig
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  3. Ansgar Schulz
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  4. Min Ae Lee-Kirsch
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  5. Joachim Roesler
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  6. Wilhelm Friedrich
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  7. Horst von Bernuth
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Corresponding author

Correspondence to Wilhelm Friedrich.

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Schuetz, C., Hoenig, M., Schulz, A. et al. Successful unrelated bone marrow transplantation in a child with chronic granulomatous disease complicated by pulmonary and cerebral granuloma formation. Eur J Pediatr 166, 785–788 (2007). https://doi.org/10.1007/s00431-006-0317-7

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  • DOI: https://doi.org/10.1007/s00431-006-0317-7

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